PD-1 blockade reverts motility arrest of transferred tumor-infiltrating CD8+T cells in adoptive cell transfer immunotherapy

被引：0
|
作者：
Mehta, Gautam [1 ,2 ]
Sukumar, Madhuhasan [2 ]
McGavern, Dorian [3 ]
Restifo, Nicholas [2 ]
机构：
[1] NINDS, Surg Neurol Branch, Bethesda, MD 20892 USA
[2] NCI, Surg Branch, Bethesda, MD 20892 USA
[3] NINDS, Viral Immunol & Intravital Imaging Sect, Bethesda, MD 20892 USA
来源：
JOURNAL OF IMMUNOLOGY | 2015年 / 194卷
关键词：
D O I：
暂无
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
TUM7P.1014
引用
收藏
页数：1
相关论文
共 50 条
  • [21] Partial absence of PD-1 expression by tumor-infiltrating EBV-specific CD8+T cells in EBV-driven lymphoepithelioma-like carcinoma
    Simoni, Yannick
    Becht, Etienne
    Li, Shamin
    Loh, Chiew Yee
    Yeong, Joe Poh Sheng
    Lim, Tony Kiat Hon
    Takano, Angela
    Tan, Daniel Shao Weng
    Newell, Evan W.
    CLINICAL & TRANSLATIONAL IMMUNOLOGY, 2020, 9 (09)
  • [22] The depths of PD-1 function within the tumor microenvironment beyond CD8+T cells
    Laba, Stephanie
    Mallett, Grace
    Amarnath, Shoba
    SEMINARS IN CANCER BIOLOGY, 2022, 86 : 1045 - 1055
  • [23] TOX-expressing terminally exhausted tumor-infiltrating CD8+ T cells are reinvigorated by co-blockade of PD-1 and TIGIT in bladder cancer
    Han, Hye Sook
    Jeong, Seongju
    Kim, Hyunglae
    Kim, Hyung-Don
    Kim, A. Reum
    Kwon, Minsuk
    Park, Su-Hyung
    Woo, Chang Gok
    Kim, Hee Kyung
    Lee, Ki Hyeong
    Seo, Sung Pil
    Kang, Ho Won
    Kim, Won Tae
    Kim, Wun-Jae
    Yun, Seok Joong
    Shin, Eui-Cheol
    CANCER LETTERS, 2021, 499 : 137 - 147
  • [24] MRI histogram analysis of tumor-infiltrating CD8+T cell levels in patients with glioblastoma
    Xue, Caiqiang
    Zhou, Qing
    Zhang, Peng
    Zhang, Bin
    Sun, Qiu
    Li, Shenglin
    Deng, Juan
    Liu, Xianwang
    Zhou, Junlin
    NEUROIMAGE-CLINICAL, 2023, 37
  • [25] PD-1 blockade-unresponsive human tumor-infiltrating CD8+ T cells are marked by loss of CD28 expression and rescued by IL-151
    Kim, Kyung Hwan
    Kim, Hong Kwan
    Kim, Hyung-Don
    Kim, Chang Gon
    Lee, Hoyoung
    Han, Ji Won
    Choi, Seong Jin
    Jeong, Seongju
    Jeon, Minwoo
    Kim, Hyunglae
    Koh, Jiae
    Ku, Bo Mi
    Park, Su-Hyung
    Ahn, Myung-Ju
    Shin, Eui-Cheol
    CELLULAR & MOLECULAR IMMUNOLOGY, 2021, 18 (02) : 385 - 397
  • [26] Rapid progression of adult T-cell leukemia/lymphoma as tumor-infiltrating Tregs after PD-1 blockade
    Rauch, Daniel A.
    Conlon, Kevin C.
    Janakiram, Murali
    Brammer, Jonathan E.
    Harding, John C.
    Ye, B. Hilda
    Zang, Xingxing
    Ren, Xiaoxin
    Olson, Sydney
    Cheng, Xiaogang
    Miljkovic, Milos D.
    Sundaramoorthi, Hemalatha
    Joseph, Ancy
    Skidmore, Zachary L.
    Griffith, Obi
    Griffith, Malachi
    Waldmann, Thomas A.
    Ratner, Lee
    BLOOD, 2019, 134 (17) : 1406 - 1414
  • [27] PD-1 blockade-unresponsive human tumor-infiltrating CD8+ T cells are marked by loss of CD28 expression and rescued by IL-15
    Kyung Hwan Kim
    Hong Kwan Kim
    Hyung-Don Kim
    Chang Gon Kim
    Hoyoung Lee
    Ji Won Han
    Seong Jin Choi
    Seongju Jeong
    Minwoo Jeon
    Hyunglae Kim
    Jiae Koh
    Bo Mi Ku
    Su-Hyung Park
    Myung-Ju Ahn
    Eui-Cheol Shin
    Cellular & Molecular Immunology, 2021, 18 : 385 - 397
  • [28] T-cell adoptive immunotherapy using tumor-infiltrating T cells and genetically engineered TCR-T cells
    Ikeda, Hiroaki
    INTERNATIONAL IMMUNOLOGY, 2016, 28 (07) : 349 - 353
  • [29] Tumor-infiltrating regulatory T cells delineated by upregulation of PD-1 and inhibitory receptors
    Park, Hyo Jin
    Kusnadi, Anthony
    Lee, Eun-Jung
    Kim, Won Woo
    Cho, Byoung Chul
    Lee, Ik Jae
    Seong, Jinsil
    Ha, Sang-Jun
    CELLULAR IMMUNOLOGY, 2012, 278 (1-2) : 76 - 83
  • [30] Clinical and Prognostic Significance of Tumor-Infiltrating CD8+T Cells and PD-L1 Expression in Primary Gastrointestinal Stromal Tumors
    Sun, Xiangfei
    Shu, Ping
    Fang, Yong
    Yuan, Wei
    Zhang, Qiang
    Sun, Jianyi
    Fu, Min
    Xue, Anwei
    Gao, Xiaodong
    Shen, Kuntang
    Hou, Yingyong
    Sun, Yihong
    Qin, Jing
    Qin, Xinyu
    FRONTIERS IN ONCOLOGY, 2021, 11
12345