Palladium-Catalyzed Direct C-H Bond Alkynylations of Heteroarenes Using gem-Dichloroalkenes

被引：49
|
作者：
Ackermann, Lutz [1 ]
Kornhaass, Christoph [1 ]
Zhu, Yingjun [1 ]
机构：
[1] Univ Gottingen, Inst Organ & Biomol Chem, D-37077 Gottingen, Germany
来源：
ORGANIC LETTERS | 2012年 / 14卷 / 07期
关键词：
DIRECT ARYLATIONS; ARYL CHLORIDES; COPPER; HETEROCYCLES; ACTIVATION; 1,3,4-OXADIAZOLES; BENZYLATIONS; CONSTRUCTION; PRELIGANDS; PARTNERS;
D O I：
10.1021/ol300514d
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Palladium-catalyzed direct alkynylations of heteroarenes were accomplished with inexpensive gem-dichloroalkenes as user-friendly electrophiles, which set the stage for a modular, step-economical synthesis of diversely decorated heteroaryl alkynes with ample scope.
引用
收藏
页码：1824 / 1826
页数：3
相关论文
共 50 条
  • [1] Palladium-Catalyzed Carbonylative C-H Activation of Heteroarenes
    Wu, Xiao-Feng
    Anbarasan, Pazhamalai
    Neumann, Helfried
    Beller, Matthias
    ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2010, 49 (40) : 7316 - 7319
  • [2] Eco-Friendly Solvents for Palladium-Catalyzed Desulfitative C-H Bond Arylation of Heteroarenes
    Hfaiedh, Anoir
    Yuan, Kedong
    Ben Ammar, Hamed
    Ben Hassine, Bechir
    Soule, Jean-Francois
    Doucet, Henri
    CHEMSUSCHEM, 2015, 8 (10) : 1794 - 1804
  • [3] Palladium- and Copper-Catalyzed Stereocontrolled Direct C-H Fluoroalkenylation of Heteroarenes using gem-Bromofluoroalkenes
    Schneider, Cedric
    Masi, Daniela
    Couve-Bonnaire, Samuel
    Pannecoucke, Xavier
    Hoarau, Christophe
    ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2013, 52 (11) : 3246 - 3249
  • [4] Palladium-catalyzed C-H ethoxycarbonyldifluoromethylation of electron-rich heteroarenes
    Shao, Changdong
    Zhang, Yanghui
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2016, 252
  • [5] No Detours: Palladium-Catalyzed Oxidative C-H/C-H Cross-Couplings of Heteroarenes
    Han, Wei
    Ofial, Armin R.
    SYNLETT, 2011, (14) : 1951 - 1955
  • [6] Palladium-Catalyzed C-H Ethoxycarbonyldifluoromethylation of Electron-Rich Heteroarenes
    Shao, Changdong
    Shi, Guangfa
    Zhang, Yanghui
    Pan, Shulei
    Guan, Xiaohong
    ORGANIC LETTERS, 2015, 17 (11) : 2652 - 2655
  • [7] Palladium-Catalyzed Direct Esterification via C-H Bond Activation of Aldehydes
    Yan, Xiao-Xiao
    Lu, Wen-Xiu
    Mao, Jian-Gang
    Xing, Jian
    Tang, Hong-Yu
    Huang, Shu-Yi
    Jiang, Wen
    JOURNAL OF ORGANIC CHEMISTRY, 2023, 88 (13): : 9026 - 9036
  • [8] Palladium-catalyzed Direct C-H Bond Arylation of Simple Arenes with Aryltrimethylsilanes
    Funaki, Kenji
    Kawai, Hiroshi
    Sato, Tetsuo
    Oi, Shuichi
    CHEMISTRY LETTERS, 2011, 40 (09) : 1050 - 1052
  • [9] Palladium-catalyzed methylation of aryl C-H bond by using peroxides
    Zhang, Yuhua
    Feng, Jianqing
    Li, Chao-Jun
    JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2008, 130 (10) : 2900 - 2901
  • [10] Palladium-Catalyzed Denitrative α-Arylation of Heteroarenes with Nitroarenes via C-H and C-NO2 Bond Activations
    Yao, Jiaxin
    Xiao, Yuxuan
    Li, Haiyan
    Yang, Xun
    Du, Jiahui
    Yin, Ying
    Feng, Lin
    Duan, Wengui
    Yu, Lin
    ORGANIC LETTERS, 2024, 26 (35) : 7307 - 7312
12345