Reduced motor facilitation during action observation in schizophrenia: A mirror neuron deficit?

被引：78
|
作者：
Enticott, Peter G. [1 ,2 ]
Hoy, Kate E. [1 ,2 ]
Herring, Sally E. [1 ,2 ]
Johnston, Patrick J. [3 ]
Daskalakis, Zafiris J. [4 ]
Fitzgerald, Paul B. [1 ,2 ]
机构：
[1] The Alfred, Alfred Psychiat Res Ctr, Sch Psychol Psychiat & Psychol Med, Melbourne, Vic 3004, Australia
[2] Monash Univ, Alfred Psychiat Res Ctr, Sch Psychol Psychiat & Psychol Med, Clayton, Vic 3800, Australia
[3] Swinburne Univ Technol, Brain Sci Inst, Hawthorn, Vic 3122, Australia
[4] Univ Toronto, Ctr Addict & Mental Hlth, Toronto, ON M5S 1A1, Canada
来源：
SCHIZOPHRENIA RESEARCH | 2008年 / 102卷 / 1-3期
关键词：
schizophrenia; social cognition; mirror neurons; transcranial magnetic stimulation; primary motor cortex; premotor cortex;
D O I：
10.1016/j.schres.2008.04.001
中图分类号：
R749 [精神病学];
学科分类号：
100205 ;
摘要：
impairments in social cognitive functioning are well documented in schizophrenia, however the neural basis of these deficits is unclear. A recent explanatory model of social cognition centers upon the activity of mirror neurons, which are cortical brain cells that become active during both the performance and observation of behavior. Here, we test for the first time whether mirror neuron functioning is reduced in schizophrenia. Fifteen individuals with schizophrenia or schizoaffective disorder and fifteen healthy controls completed a transcranial magnetic stimulation (TMS) experiment designed to assess mirror neuron activation. While patients demonstrated no abnormalities in cortical excitability, motor facilitation during action observation, putatively reflecting mirror neuron activity, was reduced in schizophrenia. Dysfunction within the mirror neuron system may contribute to the pathophysiology of schizophrenia. (c) 2008 Elsevier B.V. All rights reserved.
引用
收藏
页码：116 / 121
页数：6
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