Neuroleptics normalize increased release of interleukin-1β and tumor necrosis factor-α from monocytes in schizophrenia

被引：121

作者：

Kowalski, J ^{[1
]}

Blada, P

Kucia, K

Madej, A

Herman, ZS

机构：

[1] Med Univ Silesia, Dept Clin Pharmacol, Katowice, Poland

[2] Med Univ Silesia, Dept Psychiat, Katowice, Poland

来源：

SCHIZOPHRENIA RESEARCH | 2001年 / 50卷 / 03期

关键词：

haloperidol; IL-1; beta; monocytes; perazine; schizophrenia; TNF-alpha;

D O I：

10.1016/S0920-9964(00)00156-0

中图分类号：

R749 [精神病学];

学科分类号：

100205 ;

摘要：

Some recent reports show that schizophrenia is accompanied by changes in lymphocyte activity. This study investigated the activity of monocytes by determining their release of interleukin-1 beta (IL-1 beta) and tumor necrosis factor-alpha (TNF-alpha). Monocytes were immunomagnetically isolated from the peripheral blood of schizophrenic patients before and after neuroleptic medication and stimulated by lipopolisaccharide (LPS) in vitro. The monocytes of schizophrenic patients released significantly higher amounts of IL-1 beta and TNF-alpha than those of healthy controls. Treatment with the typical neuroleptics haloperidol and perazine decreased the release of IL-1 beta and TNF-alpha to the control levels. The study has shown that the activity of monocytes is increased in schizophrenia and that neuroleptic treatment normalizes this activity. (C) 2001 Elsevier Science B.V. All rights reserved.

引用

页码：169 / 175

页数：7

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