[1] Univ Porto, Unit Multidisciplinary Invest Biomed, Inst Biomed Sci Abel Salazar ICBAS, Dept Microscopy,Lab Cell Biol, P-4050313 Oporto, Portugal
[2] Univ Beira Interior, CICS UBI Hlth Sci Res Ctr, Rua Marques dAvila & Bolama, P-6200001 Covilha, Portugal
[3] Univ Porto, Inst Innovat & Hlth Res I3S, Rua Alfredo Allen 208, P-4200135 Oporto, Portugal
[4] Univ Beira Interior, CICS UBI Hlth Sci Res Ctr, Av Infante D Henrique, P-6200506 Covilha, Portugal