A hybrid axisymmetric flow-focusing device for monodisperse picoliter droplets

被引：16
|
作者：
Morimoto, Yuya [1 ]
Kuribayashi-Shigetomi, Kaori [1 ,2 ]
Takeuchi, Shoji [1 ,2 ]
机构：
[1] Univ Tokyo, IIS, CIRMM, Meguro Ku, Tokyo 1538505, Japan
[2] Japan Sci & Technol Agcy JST, Exploratory Res Adv Technol ERATO, Meguro Ku, Tokyo 1538505, Japan
来源：
JOURNAL OF MICROMECHANICS AND MICROENGINEERING | 2011年 / 21卷 / 05期
基金：
日本科学技术振兴机构;
关键词：
MICROFLUIDIC DEVICES; DOUBLE EMULSIONS; ENCAPSULATION; CELLS; CHIP; SU-8; STEREOLITHOGRAPHY; MICROPARTICLES; PHOTORESIST; ULTRATHICK;
D O I：
10.1088/0960-1317/21/5/054031
中图分类号：
TM [电工技术]; TN [电子技术、通信技术];
学科分类号：
0808 ; 0809 ;
摘要：
A combination of photolithography and stereolithography was successfully used to fabricate a hybrid axisymmetric flow-focusing device (h-AFFD) that produces monodisperse picoliter droplets. The h-AFFD achieved the same level of hydrodynamic performance as a monolithic AFFD produced by only stereolithography from acrylic resin. Since the h-AFFD had a narrower orifice (50 or 100 mu m in diameter), created in an SU-8 sheet by photolithography, than the monolithic AFFD, we were able to produce picoliter droplets. We also succeeded in producing monodisperse droplets encapsulating a single cell without any surface modification.
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页数：6
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