Novel alkaloids and a ceramide from Brunsvigia natalensis (Amaryllidaceae) and their anti-neoplastic activity

被引：6
|
作者：
Moodley, N. [1 ,5 ]
Crouch, N. R. [1 ,2 ]
Bastida, J. [3 ]
Mulholland, D. A. [1 ,4 ]
机构：
[1] Univ KwaZulu Natal, Sch Chem & Phys, ZA-4041 Durban, South Africa
[2] South African Natl Biodivers Inst, Biodivers Res Assessment & Monitoring, POB 52099,Berea Rd, ZA-4007 Durban, South Africa
[3] Univ Barcelona, Fac Farm & Ciencies Alimentacio, Dept Biol Sanitat & Medi Ambient, Grp Prod Nat, Barcelona 08028, Spain
[4] Univ Surrey, Dept Chem, Nat Prod Res Grp, Guildford GU2 7XH, Surrey, England
[5] Saab Grintek Def, 185 Witch Hazel Ave,Highveld Technopk, Centurion, South Africa
来源：
SOUTH AFRICAN JOURNAL OF BOTANY | 2021年 / 136卷
基金：
新加坡国家研究基金会;
关键词：
Amaryllidaceae; Anti-proliferative activity; Brunsceramide; Brunsvigia natalensis; Crouchinine; (2R)-7-Hydroxyflavan; 3-O-Methyl-epi-vittatine; SPHINGOSINE;
D O I：
10.1016/j.sajb.2020.07.029
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
Two new 5,10b-ethanophenanthridine bridge alkaloids, 3-O-methyl-epi-vittatine, 1, and crouchinine, 2, (2R)-7-hydroxyflavan, 3, and a novel ceramide, brunsceramide, were isolated from the bulbs of Brunsvigia natalensis. (2R)-7-Hydroxyflavan showed total growth inhibition in the 55-60 ppm range against the melanoma (UACC62), breast (MCF7) and renal (TK10) cancer cell lines. 3-O-Methyl-epi-vittatine, 1, and bruns-ceramide, 4, were inactive against the cell lines tested. (C) 2020 SAAB. Published by Elsevier B.V. All rights reserved.
引用
收藏
页码：40 / 44
页数：5
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