E3 ligase RCHY1 negatively regulates HDAC2

被引：12
|
作者：
Choi, Mina [1 ]
Choi, Yeong Min [2 ]
An, In-Sook [2 ]
Bae, Seunghee [1 ]
Jung, Jin Hyuk [2 ]
An, Sungkwan [1 ]
机构：
[1] Konkuk Univ, Res Inst Mol Targeted Drugs, Dept Cosmet Engn, Seoul 05029, South Korea
[2] GeneCellPharm Corp, Korea Inst Dermatol Sci, 375 Munjeong 2i Dong, Seoul 05836, South Korea
来源：
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2020年 / 521卷 / 01期
关键词：
HDAC2; RCHY1; Protein degradation; HISTONE DEACETYLASES; CELL-CYCLE; PIRH2; EXPRESSION; DEGRADATION; ROLES;
D O I：
10.1016/j.bbrc.2019.10.049
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
HDAC2, one of the class I histone deacetylase regulates epigenetic landscape through histone modification. Because HDAC2 is overexpressed in many cancers, cancer therapeutics against HDAC2 have been developed. Here we show novel mechanism of HDAC2 regulation by E3 ligase RCHY1. We found inverse correlation RCHY1 and HDAC2 levels in tumor tissue from six independent dataset using meta-analysis. Ectopic expression of RCHY1 decreased the level of HDAC2 from cancer cells including p53 wildtype, mutant and null cells. In addition, HDAC2 was increased by RCHY1 knockdown. RCHY1 directly interacts with HDAC2. Ectopic expression of wild type but not RING mutant RCHY1 increased HDAC2 levels. These data provide an evidence that RCHY1 negatively regulates HDAC2. (C) 2019 Elsevier Inc. All rights reserved.
引用
收藏
页码：37 / 41
页数：5
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