Synthesis and Antimicrobial Activity of Some New Substituted Quinoxalines

被引：31
|
作者：
El-Atawy, Mohamed A. [1 ,2 ]
Hamed, Ezzat A. [2 ]
Alhadi, Mahjoba [2 ]
Omar, Alaa Z. [2 ]
机构：
[1] Taibah Univ, Fac Sci, Chem Dept, Yanbu 46423, Saudi Arabia
[2] Alexandria Univ, Fac Sci, Chem Dept, PO 426 Ibrahemia, Alexandria 21321, Egypt
来源：
MOLECULES | 2019年 / 24卷 / 22期
关键词：
quinoxalines; antimicrobial; thioether; thioglycolic acid and pentacyclic compounds; IN-VITRO; BIOLOGICAL EVALUATION; DERIVATIVES; ANTICANCER;
D O I：
10.3390/molecules24224198
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
A number of new symmetrically and asymmetrically 2,3-disubstituted quinoxalines were synthesized through functionalization of 2,3-dichloroquinoxaline (2,3-DCQ) with a variety of sulfur and/or nitrogen nucleophiles. The structures of the obtained compounds were established based on their spectral data and elemental analysis. The antimicrobial activity for the prepared compounds was investigated against four bacterial species and two fungal strains. The symmetrically disubstituted quinoxalines 2, 3, 4, and 5 displayed the most significant antibacterial activity, while compounds 6a, 6b, and the pentacyclic compound 10 showed considerable antifungal activity. Furthermore, compounds 3f, 6b showed broad antimicrobial spectrum against most of the tested strains.
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页数：16
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