Monovalent currents through the T-type Cav3.1 channels and their block by Mg2+

被引：0
|
作者：
Kurejova, A. [1 ]
Pavlovicova, A. [1 ]
Lacinova, L. [1 ]
机构：
[1] Slovak Acad Sci, Ctr Excellence Cardiovasc Res, Inst Mol Physiol & Genet, SK-83304 Bratislava, Slovakia
来源：
GENERAL PHYSIOLOGY AND BIOPHYSICS | 2007年 / 26卷 / 03期
关键词：
T-type calcium channel; Ca(v)3.1; monovalent cations; permeability;
D O I：
暂无
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
We have investigated the permeability of the Ca(v)3.1 channel for Ca2+ and different monovalent cations and the block of the currents by Mg2+ ions. In the absence of extracellular divalent cations, the Cav3.1 channel was more permeable for Na+ than for Cs+ and impermeable for NMDG(+). Monovalent currents were inhibited by Mg2+ of near physiological concentration by three orders of magnitude more effectively than the Ca2+ current. Inhibition of outward, but not inward current by Mg2+ was voltage-dependent. Furthermore, magnesium slowed down channel deactivation presumably by interacting with an open channel state.
引用
收藏
页码：234 / 239
页数：6
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