Exercise reduces systemic immune inflammation index (SII) in childhood cancer patients

被引：17
|
作者：
Winker, Matteo [1 ]
Stoessel, Sandra [2 ]
Neu, Marie Astrid [2 ]
Lehmann, Nadine [2 ]
El Malki, Khalifa [2 ]
Paret, Claudia [2 ]
Joisten, Niklas [3 ]
Bloch, Wilhelm [1 ]
Zimmer, Philipp [3 ]
Faber, Joerg [2 ]
机构：
[1] German Sport Univ Cologne, Inst Cardiovasc Res & Sports Med, Dept Mol & Cellular Sports Med, Cologne, Germany
[2] Univ Med Ctr Mainz, Childhood Canc Ctr, Ctr Pediat & Adolescent Med, Mainz, Germany
[3] Tech Univ Dortmund, Inst Sport & Sport Sci, Dept Performance & Hlth Sports Med, Otto Hahn Str 3, D-44227 Dortmund, Germany
来源：
SUPPORTIVE CARE IN CANCER | 2022年 / 30卷 / 04期
关键词：
Tumor entities; Cellular inflammation; Pediatric oncology; Resistance training; Endurance training; QUALITY-OF-LIFE; PREDICTS SURVIVAL; CHILDREN; FATIGUE; RATIO;
D O I：
10.1007/s00520-021-06719-3
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
While exercise and physical activity have been suggested to reduce mortality and symptoms in cancer, knowledge on these associations in patients with childhood cancer (CCPs) is sparse. Anti-inflammatory properties of exercise might mediate these beneficial effects. We investigated the influence of exercise on the inflammation markers neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, and systemic-immune-inflammation index (SII) and associations to patient-reported-outcomes in CCPs in a randomized-controlled trial. Results show associations between inflammation markers and patient-reported outcomes. Compared to the control group, SII was significantly reduced following exercise (p=0.036). Anti-inflammatory effects of exercise are also present in CCPs and may underlie exercise-induced benefits on symptoms. Clinical Trial Registration Number: NCT02612025
引用
收藏
页码：2905 / 2908
页数：4
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