Fibroblast-like cells as an effective feeder for the cultivation and derivation of new lines of human induced pluripotent stem cells

被引：1
|
作者：
Novosadova, E. V. [1 ]
Manuilova, E. S. [1 ]
Arsenyeva, E. L. [1 ]
Grivennikov, I. A. [1 ]
Myasoedov, N. F. [1 ]
机构：
[1] Russian Acad Sci, Inst Mol Genet, Pl Akad Kurchatova 46, Moscow 123182, Russia
来源：
DOKLADY BIOCHEMISTRY AND BIOPHYSICS | 2016年 / 470卷 / 01期
基金：
俄罗斯基础研究基金会;
关键词：
EXPANSION;
D O I：
10.1134/S1607672916050136
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Induced pluripotent stem cells (iPSCs) can be a highly informative model of hereditary and sporadic human diseases. In the future, such cells can be used in substitution and regenerative therapy of a wide range of diseases and for the treatment of injuries and burns. The ability of iPSCs derived from patients with Parkinson's disease to differentiate into fibroblast-like cells (derivatives) was studied. It was found that these cells can serve as an effective feeder layer not only to maintain the pluripotency of allogenic and autologous iPSCs but also to derive new iPSC lines.
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页码：353 / 356
页数：4
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