Total Synthesis and Stereochemistry Assignment of Nucleoside Antibiotic A-94964

被引：8

作者：

Shao, Xiaofei ^{[1
,2
]}

Zheng, Chang ^{[1
]}

Xu, Peng ^{[2
]}

Shiraishi, Taro ^{[3
]}

Kuzuyama, Tomohisa ^{[3
,4
]}

Molinaro, Antonio ^{[5
]}

Silipo, Alba ^{[5
]}

Yu, Biao ^{[1
,2
]}

机构：

[1] Univ Chinese Acad Sci, Sch Chem & Mat Sci, Hangzhou Inst Adv Study, Hangzhou, Peoples R China

[2] Chinese Acad Sci, State Key Lab Bioorgan & Nat Prod Chem, Ctr Excellence Mol Synth, Shanghai Inst Organ Chem,Univ Chinese Acad Sci, Shanghai, Peoples R China

[3] Univ Tokyo, Grad Sch Agr & Life Sci, Tokyo, Japan

[4] Univ Tokyo, Collaborat Res Inst Innovat Microbiol, Tokyo, Japan

[5] Univ Naples Federico II, Dept Chem Sci, Naples, Italy

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2022年 / 61卷 / 14期

基金：

中国国家自然科学基金;

关键词：

A-94964; Nucleoside Antibiotic; Octuronic Acid Uridine; Phosphodiester; Total Synthesis; BACTERIAL TRANSLOCASE-I; BIOLOGICAL EVALUATION; MODULAR APPROACH; MRAY; GLYCOSYLATION; TUNICAMYCINS; INHIBITOR;

D O I：

10.1002/anie.202200818

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A collective total synthesis of eight diastereoisomers associated with NMR analysis leads to a full stereochemistry assignment of the structurally unique nucleoside antibiotic A-94964, which features an octuronic acid uridine core decorated with an alpha-D-mannopyr-anosyl residue and an alpha-D-N-acylglucosaminopyranosyl residue via a phosphodiester bridge.

引用

页数：7

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