Intramolecular azomethine ylide cycloaddition reactions to give octahydroindoles

被引：41

作者：

Coldham, I

Crapnell, KM

Moseley, JD

Rabot, R

机构：

[1] Univ Exeter, Sch Chem, Exeter EX4 4QD, Devon, England

[2] AstraZeneca Pharmaceut, Proc R&D Dept, Avlon Works, Bristol BS10 7ZE, Avon, England

来源：

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1 | 2001年 / 15期

关键词：

D O I：

10.1039/b104390k

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The aldehyde 2-formyl-2-(pent-4-enyl)-1,3-dithiane 1, containing both alkene and aldehyde functional groups, is a good substrate for intramolecular dipolar cycloaddition reactions after condensation with various N-alkyl alpha -amino-esters. This paper reports the optimization, scope and stereoselectivity of this reaction to give octahydroindoles (2-azabicyclo[4.3.0]nonanes).

引用

页码：1758 / 1763

页数：6

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