Natural Killer Cell-Based Immunotherapy in Gynecologic Malignancy: A Review

被引：42
|
作者：
Uppendahl, Locke D. [1 ]
Dahl, Carly M. [2 ]
Miller, Jeffrey S. [3 ]
Felices, Martin [3 ]
Geller, Melissa A. [1 ]
机构：
[1] Univ Minnesota, Sch Med, Div Gynecol Oncol, Dept Obstet Gynecol & Womens Hlth, Minneapolis, MN 55455 USA
[2] Univ Minnesota, Sch Med, Minneapolis, MN 55455 USA
[3] Univ Minnesota, Sch Med, Dept Med, Div Hematol Oncol & Transplantat, Minneapolis, MN 55455 USA
来源：
FRONTIERS IN IMMUNOLOGY | 2018年 / 8卷
关键词：
natural killer cells; immunotherapy; gynecologic malignancy; ovarian cancer; cervical cancer; TUMOR-INFILTRATING LYMPHOCYTES; APOPTOSIS-INDUCING LIGAND; OVARIAN-CANCER PATIENTS; CLASS-I MOLECULES; ANTI-CD20; MONOCLONAL-ANTIBODY; PERIPHERAL-BLOOD LYMPHOCYTES; IFN-GAMMA PRODUCTION; UTERINE NK CELLS; ACTIVATING RECEPTOR; ADOPTIVE TRANSFER;
D O I：
10.3389/fimmu.2017.01825
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Harnessing the immune system has proven an effective therapy in treating malignancies. Since the discovery of natural killer (NK) cells, strategies aimed to manipulate and augment their effector function against cancer have been the subject of intense research. Recent progress in the immunobiology of NK cells has led to the development of promising therapeutic approaches. In this review, we will focus on the recent advances in NK cell immunobiology and the clinical application of NK cell immunotherapy in ovarian, cervical, and uterine cancer.
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页数：15
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