Efficient synthesis of decahydroacridine-1,8-diones and polyhydroquinolines using the step-wise method

被引：1

作者：

Hosseininasab, Fatemeh Sadat ^{[1
]}

Memarian, Hamid Reza ^{[1
]}

机构：

[1] Univ Isfahan, Dept Chem, Esfahan 8174673441, Iran

来源：

RESEARCH ON CHEMICAL INTERMEDIATES | 2022年 / 48卷 / 04期

关键词：

Cyclocondensation reaction; Decahydroacridine-1,8-diones; beta-Enaminone; Multi-component reaction; Polyhydroquinolines; ONE-POT SYNTHESIS; SOLVENT-FREE; IONIC LIQUID; 1,4-DIHYDROPYRIDINE DERIVATIVES; MULTICOMPONENT REACTIONS; 4-COMPONENT SYNTHESIS; CATALYST; GREEN; ALDEHYDES; WATER;

D O I：

10.1007/s11164-021-04643-z

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Various symmetrical and unsymmetrical decahydroacridine-1,8-dione and polyhydroquinoline derivatives were synthesized via two-step cyclocondensation reactions. The advantages of this step-wise addition of reactants in comparison with other one-pot reactions are avoiding the formation of 2 or 3 undesired by-products, therefore allowing cleaner work up of reaction. The important factor of this effective cyclocondensation method is that the prepared beta-enaminone component was added dropwise to the solution, in which the Knoevenagel condensation product is slowly being formed by reaction of aldehyde molecule and 1,3-dicarbonyl compounds. The results of the proposed step-wise method are compared and discussed with those obtained in the one-pot reactions.

引用

页码：1515 / 1540

页数：26

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