Efficient synthesis of decahydroacridine-1,8-diones and polyhydroquinolines using the step-wise method

被引：1
|
作者：
Hosseininasab, Fatemeh Sadat [1 ]
Memarian, Hamid Reza [1 ]
机构：
[1] Univ Isfahan, Dept Chem, Esfahan 8174673441, Iran
来源：
RESEARCH ON CHEMICAL INTERMEDIATES | 2022年 / 48卷 / 04期
关键词：
Cyclocondensation reaction; Decahydroacridine-1,8-diones; beta-Enaminone; Multi-component reaction; Polyhydroquinolines; ONE-POT SYNTHESIS; SOLVENT-FREE; IONIC LIQUID; 1,4-DIHYDROPYRIDINE DERIVATIVES; MULTICOMPONENT REACTIONS; 4-COMPONENT SYNTHESIS; CATALYST; GREEN; ALDEHYDES; WATER;
D O I：
10.1007/s11164-021-04643-z
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Various symmetrical and unsymmetrical decahydroacridine-1,8-dione and polyhydroquinoline derivatives were synthesized via two-step cyclocondensation reactions. The advantages of this step-wise addition of reactants in comparison with other one-pot reactions are avoiding the formation of 2 or 3 undesired by-products, therefore allowing cleaner work up of reaction. The important factor of this effective cyclocondensation method is that the prepared beta-enaminone component was added dropwise to the solution, in which the Knoevenagel condensation product is slowly being formed by reaction of aldehyde molecule and 1,3-dicarbonyl compounds. The results of the proposed step-wise method are compared and discussed with those obtained in the one-pot reactions.
引用
收藏
页码：1515 / 1540
页数：26
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