Systematic Review and Meta-Analysis: Prevalence of Small Intestinal Bacterial Overgrowth in Chronic Liver Disease

被引：53
|
作者：
Shah, Ayesha [1 ,2 ,3 ]
Shanahan, Erin [1 ,3 ]
Macdonald, Graeme A. [1 ,2 ,3 ]
Fletcher, Linda [1 ,2 ]
Ghasemi, Pegah [1 ,2 ]
Morrison, Mark [1 ,4 ]
Jones, Mike [5 ]
Holtmann, Gerald [1 ,2 ,3 ]
机构：
[1] Univ Queensland, Princess Alexandra Hosp, Fac Med, Brisbane, Qld, Australia
[2] Princess Alexandra Hosp, Dept Gastroenterol & Hepatol, Brisbane, Qld, Australia
[3] Princess Alexandra Hosp, Translat Res Inst, Brisbane, Qld, Australia
[4] Univ Queensland, Diamantina Inst, Microbial Biol & Metagen, Woolloongabba, Qld, Australia
[5] Macquarie Univ, Dept Psychol, Sydney, NSW, Australia
来源：
SEMINARS IN LIVER DISEASE | 2017年 / 37卷 / 04期
关键词：
cirrhosis; bacterial overgrowth; prevalence; breath tests; NAFLD; SMALL-BOWEL MOTILITY; TRANSIT-TIME; AUTONOMIC NEUROPATHY; CIRRHOTIC-PATIENTS; GUT MICROBIOTA; TRANSLOCATION; DIAGNOSIS; PERMEABILITY; PATHOPHYSIOLOGY; ASSOCIATION;
D O I：
10.1055/s-0037-1608832
中图分类号：
R57 [消化系及腹部疾病];
学科分类号：
摘要：
The authors conducted a meta-analysis of the prevalence of small intestinal bacterial overgrowth (SIBO) in patients with chronic liver disease (CLD) and controls. Using the search terms small intestinal bacterial overgrowth (SIBO)" and "chronic liver disease (CLD)" or "cirrhosis," 19 case-control studies were identified. Utilizing breath tests, the prevalence of SIBO in CLD was 35.80% (95% CI, 32.60-39.10) compared with 8.0% (95% CI, 5.70-11.00) in controls. Using culture techniques, the prevalence was 68.31% (95% CI, 59.62-76.00) in CLD patients as compared with 7.94% (95% CI, 3.44-12.73) in controls. No difference between cirrhotic and noncirrhotic patients was found. SIBO is significantly more frequent in CLD patients as compared with controls. The association of SIBO and CLD was not confined to patients with advanced CLD, suggesting that SIBO is not a consequence of advanced liver disease but may play a role in the progression of CLD.
引用
收藏
页码：388 / 400
页数：13
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