Toxoplasma gondii aspartic protease 1 is not essential in tachyzoites

被引：9

作者：

Polonais, Valerie ^{[1
]}

Shea, Michael ^{[2
]}

Soldati-Favre, Dominique ^{[1
]}

机构：

[1] Univ Geneva, CMU, Dept Microbiol & Mol Med, CH-1211 Geneva 4, Switzerland

[2] Natl Inst Med Res, Div Parasitol, London NW7 1AA, England

来源：

EXPERIMENTAL PARASITOLOGY | 2011年 / 128卷 / 04期

关键词：

Toxoplasma gondii; Aspartic protease; Plasmepsin; HOST-CELL; PLASMODIUM-FALCIPARUM; VACUOLE PLASMEPSINS; SELECTABLE MARKER; FOOD VACUOLE; EXPRESSION; INVASION; PROTEIN; ERYTHROCYTE; INHIBITORS;

D O I：

10.1016/j.exppara.2011.05.003

中图分类号：

R38 [医学寄生虫学]; Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ; 100103 ;

摘要：

Aspartic proteases are important virulence factors for pathogens and are recognized as attractive drug targets. Seven aspartic proteases (ASPs) have been identified in Toxoplasma gondii genome. Bioinformatics and phylogenetic analyses regroup them into five monophyletic groups. Among them, TgASP1, a coccidian specific aspartic protease related to the food vacuole plasmepsins, is associated with the secretory pathway in non-dividing cells and relocalizes in close proximity to the nascent inner membrane complex (IMC) of daughter cells during replication. Despite a potential role for TgASP1 in IMC formation, the generation of a conventional knockout of the TgASP1 gene revealed that this protease is not required for T. gondii tachyzoite survival or for proper IMC biogenesis. (C) 2011 Elsevier Inc. All rights reserved.

引用

页码：454 / 459

页数：6

共 50 条

[21] The role of subtilisin proteases in invasion by Toxoplasma gondii tachyzoites
Miller, SA
Blackman, M
Carruthers, VB
Kim, K
MOLECULAR BIOLOGY OF THE CELL, 2000, 11 : 291A - 291A
[22] Developmental differentiation between tachyzoites and bradyzoites of Toxoplasma gondii
Gross, U
Bohne, W
Soete, M
Dubremetz, JF
PARASITOLOGY TODAY, 1996, 12 (01): : 30 - 33
[23] Toxoplasma gondii:: isolation of tachyzoites rhoptries and incorporation into Iscom
Garcia, JL
Gennari, SM
Navarro, IT
Machado, RZ
Sinhorini, LL
EXPERIMENTAL PARASITOLOGY, 2004, 108 (1-2) : 40 - 46
[24] Acridones Are Highly Potent Inhibitors of Toxoplasma gondii Tachyzoites
Alday, P. Holland
McConnell, Erin, V
Zarella, Jan M. Boitz
Dodean, Rozalia A.
Kancharla, Papireddy
Kelly, Jane X.
Doggett, J. Stone
ACS INFECTIOUS DISEASES, 2021, 7 (07): : 1877 - 1884
[25] Tachyzoites of Toxoplasma Gondii in Cerebrospinal Fluid: A Rare Finding
Jyothi, Shetty B.
Kini, Sangeeta
Meenakshi, B.
JOURNAL OF CYTOLOGY, 2020, 37 (03) : 153 - 154
[26] THE　ULTRASTRUCTURE　OF　TOXOPLASMA　GONDII　TACHYZOITES　AND　THE　EFFECT　OF　USNIC　ACID　ON　IT
吴杰
杨少毅
程彦斌
Journal of Xi'an Medical University, 1996, (01) : 91 - 94
[27] Cytologic detection of Toxoplasma gondii tachyzoites in cerebrospinal fluid
Brogi, E
Cibas, ES
AMERICAN JOURNAL OF CLINICAL PATHOLOGY, 2000, 114 (06) : 951 - 955
[28] Identifying the major lactate transporter of Toxoplasma gondii tachyzoites
Zeng, Joy M.
Hapuarachchi, Sanduni V.
Shafik, Sarah H.
Martin, Rowena E.
Kirk, Kiaran
van Dooren, Giel G.
Lehane, Adele M.
SCIENTIFIC REPORTS, 2021, 11 (01)
[29] Toxoplasma gondii aspartic protease 5: structural basis of substrate binding and inhibition mechanism
Chakraborty, Satadru
Deshmukh, Anuradha
Kesari, Pooja
Bhaumik, Prasenjit
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS, 2024,
[30] SPECIFIC BINDING OF NEOGLYCOPROTEINS TO TOXOPLASMA-GONDII TACHYZOITES
ROBERT, R
DELAJARRIGE, PL
MAHAZA, C
COTTIN, J
MAROTLEBLOND, A
SENET, JM
INFECTION AND IMMUNITY, 1991, 59 (12) : 4670 - 4673

← 1 2 3 4 5 →