Isolation and Stucture Elucidation of Diterpenes from Wedelia prostrata and Their Cytotoxicity Activities

被引：6

作者：

Chen Qing ^{[1
]}

Lin Jianhong ^{[1
]}

Zhao Dan ^{[1
]}

Zhu Xuan ^{[1
]}

机构：

[1] Xiamen Univ, Sch Pharmaceut Sci, Dept Pharm, Xiamen 361102, Peoples R China

来源：

CHEMICAL RESEARCH IN CHINESE UNIVERSITIES | 2016年 / 32卷 / 05期

基金：

中国国家自然科学基金; 高等学校博士学科点专项科研基金;

关键词：

Wedelia prostrata; 3 alpha-Phenylpropionoyloxy-ent-kaur-16-en-oic acid; Chemical constituent; Cytotoxicity activity; TERPENOIDS; CONSTITUENTS; DERIVATIVES; ACID; TRILOBATA; CELLS;

D O I：

10.1007/s40242-016-6122-6

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

In this paper, a new diterpene together with seven known diterpenes was isolated from Wedelia prostrata. The chemical structure of the new compound was elucidated via 1D and 2D nuclear magnetic resonance(NMR) techniques and mass spectrometry and identified to be 3 alpha-phenylpropionoyloxy-ent-kaur-16-en-oic acid(1). The isolated diterpenes were tested for their cytotoxicity activities via 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide(MTT) assay. The results show that compounds 1, 2, 3, 4 and 6 exhibit different levels of cytotoxic activities. Especially, compound 2 shows significant cytotoxicity toward HeLa and A549 cell lines(IC50=6.14 and 8.76 mu mol/L).

引用

页码：792 / 796

页数：5

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