Platelet thrombin receptors PAR1 and PAR4 act in a synergistic manner

被引：0
|
作者：
Oberg, K., V [1 ]
Kulsum, S. [1 ]
Boknas, N. [1 ]
Ramstrom, S. [2 ]
Lindahl, T. L. [3 ]
机构：
[1] Linkoping Univ, Clin Chem, Clin & Expt Med, Linkoping, Sweden
[2] Royal Coll Surg Dublin, Dublin, Ireland
[3] Univ Hosp, Lab Med, Linkoping, Sweden
来源：
JOURNAL OF THROMBOSIS AND HAEMOSTASIS | 2009年 / 7卷
关键词：
D O I：
暂无
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
PP-WE-014
引用
收藏
页码：629 / 629
页数：1
相关论文
共 50 条
  • [41] PAR1 antagonists inhibit thrombin-induced platelet activation whilst leaving the PAR4-mediated response intact
    Judge, Heather M.
    Jennings, Lisa K.
    Moliterno, David J.
    Hord, Edward
    Ecob, Rosemary
    Tricoci, Pierluigi
    Rorick, Tyrus
    Kotha, Jayaprakash
    Storey, Robert F.
    PLATELETS, 2015, 26 (03) : 236 - 242
  • [42] The Common PAR4 Ala120Thr Variant Has a Major Effect on Platelet Reactivity to Thrombin and These Effects Are Enhanced with PAR1 and P2Y12 Inhibition
    Whitley, Michael J.
    Vesci, Joanne
    Holinstat, Michael
    Edelstein, Leonard C.
    Bray, Paul F.
    BLOOD, 2016, 128 (22)
  • [43] Common variants in the human platelet PAR4 thrombin receptor alter platelet function and differ by race
    Edelstein, Leonard C.
    Simon, Lukas M.
    Lindsay, Cory R.
    Kong, Xianguo
    Teruel-Montoya, Raul
    Tourdot, Benjamin E.
    Chen, Edward S.
    Ma, Lin
    Coughlin, Shaun
    Nieman, Marvin
    Holinstat, Michael
    Shaw, Chad A.
    Bray, Paul F.
    BLOOD, 2014, 124 (23) : 3450 - 3458
  • [44] Platelet responsiveness to PAR4 activation in a healthy population and its inhibition by a potent and selective PAR4 antagonist
    Downes, K.
    Astle, W.
    McKinney, H.
    Kempster, C.
    Batista, J.
    Garner, S.
    Allegretto, N.
    Ouwehand, W. H.
    Yang, J.
    EUROPEAN HEART JOURNAL, 2016, 37 : 1017 - 1017
  • [45] Coagulation Factor Xa Has No Effects on the Expression of PAR1, PAR2, and PAR4 and No Proinflammatory Effects on HL-1 Cells
    Ruf, Lukas
    Bukowska, Alicja
    Gardemann, Andreas
    Goette, Andreas
    CELLS, 2023, 12 (24)
  • [46] Protease-activated receptor 1 (PAR1) signalling desensitization is counteracted via PAR4 signalling in human platelets
    Falker, Knut
    Haglund, Linda
    Gunnarsson, Peter
    Nylander, Martina
    Lindahl, Tomas L.
    Grenegard, Magnus
    BIOCHEMICAL JOURNAL, 2011, 436 : 469 - 480
  • [47] PAR1、PAR4在宫颈癌中的表达及临床意义
    侯丽娟
    翟建军
    陕西医学杂志, 2017, 46 (07) : 967 - 969+972
  • [48] Complement factor C4a does not activate protease-activated receptor 1 (PAR1) or PAR4 on human platelets
    Han, Xu
    de la Fuente, Maria
    Nieman, Marvin T.
    RESEARCH AND PRACTICE IN THROMBOSIS AND HAEMOSTASIS, 2021, 5 (01) : 104 - 110
  • [49] Preventing Platelet Thrombosis With a PAR1 Pepducin
    Abdel-Latif, Ahmed
    Smyth, Susan S.
    CIRCULATION, 2012, 126 (01) : 13 - 15
  • [50] Substrate-assisted catalysis of PAR1 by thrombin
    Jacques, SL
    Kuliopoulos, A
    FASEB JOURNAL, 2000, 14 (08): : A1533 - A1533
12345