Oncolytic virotherapy in veterinary medicine: current status and future prospects for canine patients

被引：35

作者：

Patil, Sandeep S. ^{[1
]}

Gentschev, Ivaylo ^{[1
,2
]}

Nolte, Ingo ^{[3
]}

Ogilvie, Gregory ^{[4
,5
]}

Szalay, Aladar A. ^{[1
,2
,5
,6
,7
]}

机构：

[1] Univ Wurzburg, Dept Biochem, D-97074 Wurzburg, Germany

[2] Genelux Corp, San Diego Sci Ctr, San Diego, CA USA

[3] Univ Vet Med, Small Anim Clin, D-30173 Hannover, Germany

[4] Calif Vet Specialists, Angel Care Canc Ctr, Carlsbad, CA 92008 USA

[5] Univ Calif San Diego, Dept Radiat Oncol, Moores Canc Ctr, La Jolla, CA 92093 USA

[6] Univ Wurzburg, Rudolf Virchow Ctr Expt Biomed, D-97078 Wurzburg, Germany

[7] Univ Wurzburg, Inst Mol Infect Biol, D-97078 Wurzburg, Germany

来源：

JOURNAL OF TRANSLATIONAL MEDICINE | 2012年 / 10卷

关键词：

cancer; canine cancer therapy; oncolytic virus; oncolysis; target molecule; combination therapy; ENDOTHELIAL GROWTH-FACTOR; REPLICATION-COMPETENT ADENOVIRUS; THYMIDINE KINASE-ACTIVITY; MESENCHYMAL STEM-CELLS; VACCINIA VIRUS; ANTITUMOR-ACTIVITY; IMMUNOHISTOCHEMICAL EXPRESSION; INTRATUMORAL SPREAD; MALIGNANT-LYMPHOMA; SYSTEMIC DELIVERY;

D O I：

10.1186/1479-5876-10-3

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Oncolytic viruses refer to those that are able to eliminate malignancies by direct targeting and lysis of cancer cells, leaving non-cancerous tissues unharmed. Several oncolytic viruses including adenovirus strains, canine distemper virus and vaccinia virus strains have been used for canine cancer therapy in preclinical studies. However, in contrast to human studies, clinical trials with oncolytic viruses for canine cancer patients have not been reported. An 'ideal' virus has yet to be identified. This review is focused on the prospective use of oncolytic viruses in the treatment of canine tumors - a knowledge that will undoubtedly contribute to the development of oncolytic viral agents for canine cancer therapy in the future.

引用

页数：10

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