Reactions to latex products are reportedly occurring with an increased frequency both in patients and in health care providers. Natural rubber latex is found in numerous products, and adverse latex reactions range from contact dermatitis to life-threatening anaphylaxis. A complete understanding of the pathophysiology of latex allergy provides the foundation for the proper diagnosis and treatment of patients with latex allergy. This article provides the reader with a review of latex allergy and suggests strategies for the management of patients with latex hypersensitivity.