pH-sensitive magnetic alginate-chitosan beads for albendazole delivery

被引：18

作者：

Wang, Fa-Qin ^{[1
,2
]}

Li, Ping ^{[1
]}

Zhang, Jun-Ping ^{[3
]}

Wang, Ai-Qin ^{[3
]}

Wei, Qin ^{[1
]}

机构：

[1] Lanzhou Univ, Hosp 2, Lanzhou 730030, Peoples R China

[2] Lanzhou Univ, Coll Pharm, Lanzhou 730030, Peoples R China

[3] Chinese Acad Sci, Lanzhou Inst Chem Phys, Lanzhou 730000, Peoples R China

来源：

PHARMACEUTICAL DEVELOPMENT AND TECHNOLOGY | 2011年 / 16卷 / 03期

关键词：

pH sensitive; magnetic beads; albendazole; chitosan; delivery properties; IRON-OXIDE NANOPARTICLES; GEL BEADS; CALCIUM-ALGINATE; DRUG-RELEASE; SUSPENSION; STABILITY; PRAZIQUANTEL; MEBENDAZOLE; IMPROVEMENT; BEHAVIOR;

D O I：

10.3109/10837451003592217

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Novel magnetic alginate-chitosan beads were prepared for the controlled delivery of albendazole. The magnetic beads were characterized by Fourier transform infrared spectroscopy (FTIR), scanning electron microscope (SEM), and vibrating sample magnetometry (VSM). The swelling behavior and in vitro release of albendazole from the beads has been investigated. The magnetic hydrogel beads had showed unique pH-dependent swelling behaviors and a continuous release of the entrapped albendazole occurred. From the magnetometer measurements data, the magnetic alginate-chitosan beads also had superparamagnetic property as well as fast magnetic response. The magnetic beads may be used as a magnetic drug targeting system for albendazole in the gastrointestinal tract.

引用

页码：228 / 236

页数：9

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