Co-existence of ossification of the nuchal ligament is associated with severity of ossification in the whole spine in patients with cervical ossification of the posterior longitudinal ligament -A multi-center CT study-

被引：19

作者：

Yoshii, Toshitaka ^{[1
,19
]}

Hirai, Takashi ^{[1
,19
]}

Iwanami, Akio ^{[2
,19
]}

Nagoshi, Narihito ^{[2
,19
]}

Takeuchi, Kazuhiro ^{[3
,19
]}

Mori, Kanji ^{[4
,19
]}

Yamada, Tsuyoshi ^{[1
,19
]}

Seki, Shoji ^{[5
,19
]}

Tsuji, Takashi ^{[2
,19
]}

Fujiyoshi, Kanehiro ^{[2
,19
]}

Furukawa, Mitsuru ^{[2
,19
]}

Nishimura, Soraya ^{[2
,19
]}

Wada, Kanichiro ^{[6
,19
]}

Koda, Masao ^{[7
,19
]}

Furuya, Takeo ^{[7
,19
]}

Matsuyama, Yukihiro ^{[8
,19
]}

Hasegawa, Tomohiko ^{[8
,19
]}

Takeshita, Katsushi ^{[9
,19
]}

Kimura, Atsushi ^{[9
,19
]}

Abematsu, Masahiko ^{[10
,19
]}

Haro, Hirotaka ^{[11
,19
]}

Ohba, Tetsuro ^{[11
,19
]}

Watanabe, Masahiko ^{[12
,19
]}

Katoh, Hiroyuki ^{[12
,19
]}

Watanabe, Kei ^{[13
,19
]}

Ozawa, Hiroshi ^{[14
,19
]}

Kanno, Haruo ^{[15
,19
]}

Imagama, Shiro ^{[16
,19
]}

Ando, Kei ^{[16
,19
]}

Fujibayashi, Shunsuke ^{[17
,19
]}

Matsumoto, Morio ^{[2
,19
]}

Nakamura, Masaya ^{[2
,19
]}

Yamazaki, Masashi ^{[18
,19
]}

Okawa, Atsushi ^{[1
,19
]}

Kawaguchi, Yoshiharu ^{[5
,19
]}

机构：

[1] Tokyo Med & Dent Univ, Dept Orthoped Surg, Bunkyo Ward, 1-5-45 Yushima, Tokyo 1138519, Japan

[2] Keio Univ, Sch Med, Dept Orthoped Surg, Shinjuku Ward, 35 Shinanomachi, Tokyo 1608582, Japan

[3] Natl Hosp Org Okayama Med Ctr, Dept Orthoped Surg, 1711-1 Tamasu, Okayama, Okayama 7011154, Japan

[4] Shiga Univ Med Sci, Dept Orthoped Surg, Tsukinowa Cho, Otsu, Shiga 5202192, Japan

[5] Toyama Univ, Fac Med, Dept Orthoped Surg, 2630 Sugitani, Toyama, Toyama 9300194, Japan

[6] Hirosaki Univ, Grad Sch Med, Dept Orthoped Surg, 53 Honcho, Hirosaki, Aomori 0368203, Japan

[7] Chiba Univ, Grad Sch Med, Dept Orthoped Surg, Chuo Ward, 1-8-1 Inohana, Chiba, Chiba 2600856, Japan

[8] Hamamatsu Univ, Sch Med, Dept Orthoped Surg, 1-20-1 Handayama, Hamamatsu, Shizuoka 4313125, Japan

[9] Jichi Med Univ, Dept Orthoped, 3311-1 Yakushiji, Shimotsuke, Tochigi 3290498, Japan

[10] Kagoshima Univ, Dept Orthoped Surg, Grad Sch Med & Dent Sci, 8-35-1 Sakuragaoka, Kagoshima, Kagoshima 8908520, Japan

[11] Univ Yamanashi, Dept Orthoped Surg, Chuo Ward, 1110 Shimokato, Yamanashi 4093898, Japan

[12] Tokai Univ, Sch Med, Dept Orthoped Surg, Surg Sci, 143 Shimokasuya, Isehara, Kanagawa 2591143, Japan

[13] Niigata Univ Med & Dent Gen Hosp, Dept Orthoped Surg, Chuo Ward, 1-754 Asahimachidori, Niigata, Niigata 9518520, Japan

[14] Tohoku Med & Pharmaceut Univ, Dept Orthopaed Surg, Miyagino Ku, 1-12-1 Fukumuro, Sendai, Miyagi 9838512, Japan

[15] Tohoku Univ, Sch Med, Dept Orthopaed Surg, Aoba Ward, 1-1 Seiryomachi, Sendai, Miyagi 9808574, Japan

[16] Nagoya Univ, Grad Sch Med, Dept Orthoped Surg, Showa Ward, 65 Tsurumaicho, Nagoya, Aichi 4660065, Japan

[17] Kyoto Univ, Grad Sch Med, Dept Orthoped Surg, Sakyo Ward, 54 Kawaharacho, Kyoto, Kyoto 6068507, Japan

[18] Univ Tsukuba, Fac Med, Dept Orthoped Surg, 2-1-1 Amakubo, Tsukuba, Ibaraki 3058576, Japan

[19] Japanese Multictr Res Org Ossificat Spinal Ligame, Otsu, Shiga, Japan

来源：

JOURNAL OF ORTHOPAEDIC SCIENCE | 2019年 / 24卷 / 01期

关键词：

SKELETAL HYPEROSTOSIS DISH; PREVALENCE; FRACTURE; LUMBAR;

D O I：

10.1016/j.jos.2018.08.009

中图分类号：

R826.8 [整形外科学]; R782.2 [口腔颌面部整形外科学]; R726.2 [小儿整形外科学]; R62 [整形外科学（修复外科学）];

学科分类号：

摘要：

Background: Previous studies have shown that patients with cervical ossification of the posterior longitudinal ligament (OPLL) often have co-existing ossification of the nuchal ligament (ONL). However, no studies have focused on ONL and its relevance to the severity of OPLL or ossification of other spinal ligaments, such as anterior longitudinal ligament (OALL), ligamentum flavum (OLF), and supraspinous/interspinous ligament (OSIL). Methods: In this multicenter study, we investigated ossification of the spinal ligaments in the whole spine computed tomography (CT) images of 233 cervical OPLL patients. The severity of ossification was evaluated using ossification index for each spinal ligament, calculated as the sum of the level of ossification. We compared the severity of ossification in each spinal ligament between patients with ONL and those without ONL. Furthermore, we investigated how the number of segments, where ONL exists, affects the severity of ossification in each spinal ligament. Results: One hundred thirty patients (55.8%) had co-existing ONL in the cervical OPLL patients included in this study. The ONL (+) group included more male and aged patients. The cervical ossification indexes of OPLL and OALL were higher in ONL (+) patients than in ONL (-) patients. The thoracolumbar ossification indexes of OALL and OSIL were also higher in ONL (+) patients. Logistic regression analysis revealed that age, gender and cervical OA-index were independent factors correlating to the existence of ONL. In the cervical spine, both the ossification indexes of OALL and OPLL increased as the levels of ONL increased. Similarly, in the thoracolumbar spine, both the ossification indexes of OALL and OSIL were increased as the levels of cervical ONL increased. In the multiple regression analysis, cervical OA-index and thoracolumbar OSI-index showed significant correlation with the number of ONL levels. Conclusions: Co-existence of ONL in cervical OPLL patients was associated with the severity of spinal hyperostosis especially in cervical OPLL, OALL, thoracolumbar OALL and OSIL. (C) 2018 The Japanese Orthopaedic Association. Published by Elsevier B.V. All rights reserved.

引用

页码：35 / 41

页数：7

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