Multi-Target Stool DNA Test: A New High Bar for Noninvasive Screening

被引:53
|
作者
Ahlquist, David A. [1 ]
机构
[1] Mayo Clin, Div Gastroenterol & Hepatol, Rochester, MN 55905 USA
关键词
Colorectal cancer; Colorectal polyps; Molecular detection; Fecal blood testing; FIT; HIGH-GRADE DYSPLASIA; INTERVAL COLORECTAL CANCERS; SESSILE SERRATED POLYPS; METHYLATED SEPT9 DNA; SOCIETY TASK-FORCE; ULCERATIVE-COLITIS; NATURAL-HISTORY; DETECTION RATES; MISS RATES; COLONOSCOPY;
D O I
10.1007/s10620-014-3451-5
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
Stool DNA testing has evolved into what is now a highly accurate and well-validated test for the screen detection of colorectal neoplasia. An optimized and automated multi-target stool DNA test (MT-sDNA) has achieved the same high point-sensitivities as reported for colonoscopy and significantly higher sensitivity than by fecal immunochemical blood testing for detection of early-stage cancer and advanced precancer. Thus, MT-sDNA sets a new high criterion standard for the noninvasive screen detection of colorectal neoplasia. With clinical application, MT-sDNA has potential to meaningfully address current gaps in our approach to CRC screening through benefits of its high accuracy on screening effectiveness, user-friendly features on patient compliance, and easy mail-out distribution on test access. The US Food and Drug Administration and Center for Medicaid and Medicare Services have recently completed their parallel reviews of MT-sDNA, which has just become available for clinical use. This review summarizes the recent clinical validation data on MT-sDNA, addresses central clinical questions at this front end of implementation, and touches on innovative future applications of stool DNA testing.
引用
收藏
页码:623 / 633
页数:11
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