Recombinant CD19 Glycomutant Accurately and Reproducibly Detects CD19-Directed CAR-T Cells By Flow Cytometry

被引:1
|
作者
Kirchmeier, Delaney R. [1 ]
Sheih, Alyssa [2 ,3 ]
Fiorenza, Salvatore [3 ]
Hirayama, Alexandre V. [3 ]
Chou, Cassie [3 ,4 ]
Kimble, Erik [3 ,5 ]
Gauthier, Jordan [3 ]
Williams, Alison [3 ]
Price, Jason [3 ]
Correnti, Colin [3 ,6 ]
Turtle, Cameron J. [3 ,5 ]
机构
[1] Fred Hutchinson Canc Res Ctr, 1124 Columbia St, Seattle, WA 98104 USA
[2] Umoja Biopharma, Seattle, WA USA
[3] Fred Hutchinson Canc Res Ctr, Div Clin Res, 1124 Columbia St, Seattle, WA 98104 USA
[4] Genentech Inc, San Francisco, CA 94080 USA
[5] Univ Washington, Dept Med, Seattle, WA USA
[6] Link Immunotherapeut, Seattle, WA USA
关键词
D O I
10.1182/blood-2021-148229
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
1724
引用
收藏
页数:4
相关论文
共 50 条
  • [41] Characteristics and risk factors of infections following CD28-based CD19 CAR-T cells
    Dayagi, Talya Wittmann
    Sherman, Gilad
    Bielorai, Bella
    Adam, Etai
    Besser, Michal J.
    Shimoni, Avichai
    Nagler, Arnon
    Toren, Amos
    Jacoby, Elad
    Avigdor, Abraham
    LEUKEMIA & LYMPHOMA, 2021, 62 (07) : 1692 - 1701
  • [42] The Safety and Efficacy of p CAR-19B, a Scfv Humanlized CD19-Directed CAR-T for Patients with Relapsed/Refactory (R/R) CD19+B-ALL
    Hong, Zhenya
    Yang, Zhi
    Zhou, Xiaoxi
    Wang, Gaoxiang
    Zhou, Mi
    Zhang, Yingzi
    Zhang, Peiling
    Huang, Jinjin
    Meng, Li
    Ruan, Haitao
    Xiao, Min
    Li, Yunyan
    Wang, Linling
    Wang, Meiling
    Zhu, Wei
    Zhang, Qianzhen
    Shen, Junjie
    Zhou, Jianfeng
    Qian, Cheng
    Huang, Liang
    BLOOD, 2022, 140 : 4625 - 4626
  • [43] Super-resolution microscopy reveals ultra-low CD19 expression on myeloma cells that triggers elimination by CD19 CAR-T
    Nerreter, Thomas
    Letschert, Sebastian
    Goetz, Ralph
    Doose, Soeren
    Danhof, Sophia
    Einsele, Hermann
    Sauer, Markus
    Hudecek, Michael
    NATURE COMMUNICATIONS, 2019, 10 (1)
  • [44] Super-resolution microscopy reveals ultra-low CD19 expression on myeloma cells that triggers elimination by CD19 CAR-T
    Thomas Nerreter
    Sebastian Letschert
    Ralph Götz
    Sören Doose
    Sophia Danhof
    Hermann Einsele
    Markus Sauer
    Michael Hudecek
    Nature Communications, 10
  • [45] Immune function assessing of TIM3/CD28-modified CD19 CAR-T cells and general CD19 CAR-T cells through a high-throughput single-cell microarray platform
    Wang, Chao
    Wang, Chunhua
    Liu, Huimin
    Zhao, Songbo
    Qiu, Jiaoyan
    Li, Ping
    Liu, Zhongqian
    Sun, Mingyuan
    Shao, Xiaowei
    Wang, Yihe
    Liang, Xiaohong
    Gao, Lifen
    Ma, Chunhong
    Song, Wei
    Zhang, Yu
    Han, Lin
    INTERDISCIPLINARY MEDICINE, 2024, 2 (01):
  • [46] CD19 CAR T cells: Prototypes for living drugs
    Sadelain, Michel
    Riviere, Isabelle
    BULLETIN DE L ACADEMIE NATIONALE DE MEDECINE, 2024, 208 (09): : 1288 - 1298
  • [47] Delayed remission following sequential infusion of humanized CD19-and CD22-modified CAR-T cells in a patient with relapsed/refractory acute lymphoblastic leukemia and prior exposure to murine-derived CD19-directed CAR-T cells
    Yang, Fei
    Zhang, Jian
    Zhang, Xinyou
    Tian, Mengli
    Wang, Jingjing
    Kang, Liqing
    Qiu, Huiying
    Wu, Depei
    ONCOTARGETS AND THERAPY, 2019, 12 : 2187 - 2191
  • [48] Directed Evolution of Stabilized Monomeric CD19 for Monovalent CAR Interaction Studies and Monitoring of CAR-T Cell Patients
    Laurent, Elisabeth
    Sieber, Anna
    Salzer, Benjamin
    Wachernig, Anna
    Seigner, Jacqueline
    Lehner, Manfred
    Geyeregger, Rene
    Kratzer, Bernhard
    Jager, Ulrich
    Kunert, Renate
    Pickl, Winfried F.
    Traxlmayr, Michael W.
    ACS SYNTHETIC BIOLOGY, 2021, 10 (05): : 1184 - 1198
  • [49] Functional signature of CD19 CAR transduced T cells
    Magalhaes, I
    Mattsson, J.
    Uhlin, M.
    EUROPEAN JOURNAL OF IMMUNOLOGY, 2016, 46 : 123 - 123
  • [50] CD19 CAR-T cells combined with ibrutinib to induce complete remission in CLL.
    Gill, Saar
    Frey, Noelle V.
    Hexner, Elizabeth
    Lacey, Simon F.
    Melenhorst, Jan Joseph
    Byrd, John C.
    Metzger, Susan
    Marcus, Taylor
    Gladney, Whitney
    Marcucci, Katherine
    Hwang, Wei-Ting
    June, Carl H.
    Porter, David L.
    JOURNAL OF CLINICAL ONCOLOGY, 2017, 35