Metabolic genetic polymorphisms and susceptibility to lung cancer

被引：36
|
作者：
Bouchardy, C
Benhamou, S
Jourenkova, N
Dayer, P
Hirvonen, A
机构：
[1] Geneva Canc Registry, CH-1205 Geneva, Switzerland
[2] Inst Gustave Roussy, Canc Epidemiol Unit, INSERM U521, Villejuif, France
[3] Univ Hosp Geneva, Div Clin Pharmacol, Geneva, Switzerland
[4] Finnish Inst Occupat Hlth, Dept Ind Hyg & Toxicol, Helsinki, Finland
来源：
LUNG CANCER | 2001年 / 32卷 / 02期
关键词：
lung cancer; carcinogen; metabolism; enzyme; genotype; polymorphism; tobacco consumption; epidemiology;
D O I：
10.1016/S0169-5002(00)00215-4
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Activity of some enzymes implicated in the metabolism of tobacco carcinogens presents a great variability between individuals due to the existence of a polymorphism in gene coding for these enzymes. Individual susceptibility to develop lung cancer could therefore depend not only on exposure to tobacco smoking, but also on genetic capacity to activate or inactivate tobacco carcinogens. This article summarizes the state of knowledge on metabolic polymorphisms and lung cancer susceptibility, and opens the discussion on the future direction of this promising way of research. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.
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页码：109 / 112
页数：4
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