Tumor formation suppressed in γδT knock-out mice

被引：8

作者：

Zhang, BN

Watanabe, S

Kohyama, M

Saijo, K

Kusakabe, M

Ohno, T

机构：

[1] RIKEN, Cell Bank, Tsukuba Sci City, Ibaraki 3050074, Japan

[2] RIKEN, Anim Lab, Tsukuba Sci City, Ibaraki 3050074, Japan

来源：

CANCER LETTERS | 2000年 / 153卷 / 1-2期

基金：

日本科学技术振兴机构;

关键词：

hepatoma; alpha beta T-KO mice; gamma delta T-KO mice; tumor suppression;

D O I：

10.1016/S0304-3835(00)00343-8

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Tumor formation was examined in mice in which the beta -chain gene of alpha betaT was knocked out (alpha betaT-KO mice) or the delta -chain gene of gamma deltaT was knocked out (gamma deltaT-KO mice). Development of Hepa 1-6 cell hepatoma was observed in six of six alpha betaT-KO mice, in four of six wild-type mice. and in only one of six gamma deltaT-KO mice. These results imply that gamma deltaT cells play a role in suppression of killer cell activity in tumor-bearing mice. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.

引用

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页码：63 / 66

页数：4

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