Tumor formation suppressed in γδT knock-out mice

被引：8
|
作者：
Zhang, BN
Watanabe, S
Kohyama, M
Saijo, K
Kusakabe, M
Ohno, T
机构：
[1] RIKEN, Cell Bank, Tsukuba Sci City, Ibaraki 3050074, Japan
[2] RIKEN, Anim Lab, Tsukuba Sci City, Ibaraki 3050074, Japan
来源：
CANCER LETTERS | 2000年 / 153卷 / 1-2期
基金：
日本科学技术振兴机构;
关键词：
hepatoma; alpha beta T-KO mice; gamma delta T-KO mice; tumor suppression;
D O I：
10.1016/S0304-3835(00)00343-8
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Tumor formation was examined in mice in which the beta -chain gene of alpha betaT was knocked out (alpha betaT-KO mice) or the delta -chain gene of gamma deltaT was knocked out (gamma deltaT-KO mice). Development of Hepa 1-6 cell hepatoma was observed in six of six alpha betaT-KO mice, in four of six wild-type mice. and in only one of six gamma deltaT-KO mice. These results imply that gamma deltaT cells play a role in suppression of killer cell activity in tumor-bearing mice. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.
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页码：63 / 66
页数：4
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