Acute microcystin-LR exposure interfere thyroid hormones homeostasis in adult zebrafish (Dania rerio)

被引:14
|
作者
Gao, Yu [1 ,2 ]
Liu, Zidong [3 ]
Jia, Dan [1 ,2 ]
Hu, Qing [1 ,2 ]
Li, Li [3 ,4 ]
Tang, Rong [3 ,4 ]
Li, Dapeng [3 ,4 ]
机构
[1] Yunnan Agr Univ, Coll Anim Sci & Technol, Kunming 650201, Yunnan, Peoples R China
[2] Key Lab Plateau Fishery Resources Conservat & Sus, Kunming 650201, Yunnan, Peoples R China
[3] Huazhong Agr Univ, Coll Fisheries, Hubei Prov Engn Lab Pond Aquaculture, Wuhan 430070, Peoples R China
[4] Freshwater Aquaculture Collaborat Innovat Ctr Hub, Wuhan 430070, Peoples R China
关键词
Microcystin-LR; Thyroid hormones; Complement component 9; Iodothyronine deiodinases activity; IODOTHYRONINE DEIODINASE EXPRESSION; PROTEIN-KINASE-C; ENDOCRINE DISRUPTION; IMMUNE-SYSTEM; FEMALE ZEBRAFISH; LAKE TAIHU; RECEPTORS; FISH; AXIS; METABOLISM;
D O I
10.1016/j.chemosphere.2019.125258
中图分类号
X [环境科学、安全科学];
学科分类号
08 ; 0830 ;
摘要
Microcystin-LR (MC-LR) in the aquatic environment may disturb thyroid hormone (TH) homeostasis. It is not clear how MC-LR affects downstream biological processes after TH disturbance. After exposure to 50, 100, 200 and 400 mu g/L MC-LR for 24, 48, 72, or 96 h, alterations of the TH metabolism of adult zebrafish at thyroxine (T4), triiodothyronine (T3) levels, and iodothyronine deiodinase (Dio) activity, were observed. After exposure to MC-LR at 400 mu g/L, T3 and T4 levels decreased significantly in females (p <0.05) and returned to normal levels at 96 h. In males, T4 levels were not significantly different between groups. The expression of corticotropin releasing hormone, thyroid-stimulating hormone beta subunit, transthyretin, sodium/iodide cotransporter, thrombopoietin, thyroid hormone receptor alpha and beta changed, but not in a dose-dependent manner. Acute MC-LR exposure induced a negative feedback regulation of the hypothalamic-pituitary-thyroid axis in adult zebrafish, and females were more sensitive than males. In conclusion, acute MC-LR exposure disrupted the TH metabolism by altering Dio activity and gene expression of the HPT axis; these changes may affect the complement system through regulation of c9 mRNA synthesis. (C) 2019 Published by Elsevier Ltd.
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页数:10
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