An electrochemical DNA biosensor for the detection of DNA damage caused by radioactive iodine and technetium

被引：0
|
作者：
Kara, Pinar
Dagdeviren, Kagan
Oezsoez, Mehmet [1 ]
机构：
[1] Ege Univ, Fac Pharm, Dept Analyt Chem, Izmir, Turkey
[2] Dokuz Eylul Univ, Fac Med, Dept Nucl Med, Izmir, Turkey
来源：
TURKISH JOURNAL OF CHEMISTRY | 2007年 / 31卷 / 03期
关键词：
Electrochemistry; DNA damage; Tc-99m; iodine-131;
D O I：
暂无
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A DNA damage process by radioactive iodine (I-131) and technetium (Tc-99m) is described. The procedure relies on a label-free electrochemical DNA biosensor. Fish sperm double stranded DNA was immobilized onto a carbon paste electrode (CPE) by electro deposition and the changes to the guanine oxidation signal were observed upon exposure to radioactive I-131 and Tc-99m by differential pulse voltammetry (DPV). The changes to the signal of guanine after exposure to therapeutic doses of Tc-99m and I-131 showed conformational changes in DNA molecules.
引用
收藏
页码：243 / 249
页数：7
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