Anti-cancer effect of Petasites hybridus L. (Butterbur) root extract on breast cancer cell lines

被引：7

作者：

Tzoneva, Rumiana ^{[1
]}

Uzunova, Veselina ^{[1
]}

Stoyanova, Tihomira ^{[1
]}

Borisova, Borislava ^{[1
]}

Momchilova, Albena ^{[1
]}

Pankov, Roumen ^{[2
]}

Maslenkova, Liliana ^{[1
]}

机构：

[1] Bulgarian Acad Sci, Inst Biophys & Biomed Engn, Dept Lipid Prot Interact, Akad G Bonchev Str,Bldg 21, Sofia 1113, Bulgaria

[2] Sofia Univ, Fac Biol, Dept Cytol Histol & Embryol, Sofia, Bulgaria

来源：

BIOTECHNOLOGY & BIOTECHNOLOGICAL EQUIPMENT | 2021年 / 35卷 / 01期

关键词：

Petasites hybridus; cancer cells; cytotoxicity; apoptosis; PROLIFERATION; BAKKENOLIDES; APOPTOSIS;

D O I：

10.1080/13102818.2021.1932594

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

In this study, we present initial data for the potential anti-cancer effects of standardized Bulgarian Petasites hybridus root extract against breast cancer cells. The results showed that Butterbur extract (BE) caused a dose-dependent selective reduction in viability with concomitant increase of apoptosis in human breast cancer cells after 72h treatment. We found the highest cytotoxicity of BE to MDA-MB-231 cells (IC50 - 520 mu g/mL), followed by the MCF-7 cancer cell line (IC50 - 865 mu g/mL). At the same time, the extract exhibited very low cytotoxicity to the non-tumorigenic L929 cell line (two-fold higher inhibitory concentration - 1252 mu g/mL). As a result of our experiments we made the conclusion that Butterbur root extract shows selective high cytotoxicity and nucleus alterations in cancer cells comparing to non-cancerous cells.

引用

页码：853 / 861

页数：9

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