Anti-cancer effect of Petasites hybridus L. (Butterbur) root extract on breast cancer cell lines

被引：7
|
作者：
Tzoneva, Rumiana [1 ]
Uzunova, Veselina [1 ]
Stoyanova, Tihomira [1 ]
Borisova, Borislava [1 ]
Momchilova, Albena [1 ]
Pankov, Roumen [2 ]
Maslenkova, Liliana [1 ]
机构：
[1] Bulgarian Acad Sci, Inst Biophys & Biomed Engn, Dept Lipid Prot Interact, Akad G Bonchev Str,Bldg 21, Sofia 1113, Bulgaria
[2] Sofia Univ, Fac Biol, Dept Cytol Histol & Embryol, Sofia, Bulgaria
来源：
BIOTECHNOLOGY & BIOTECHNOLOGICAL EQUIPMENT | 2021年 / 35卷 / 01期
关键词：
Petasites hybridus; cancer cells; cytotoxicity; apoptosis; PROLIFERATION; BAKKENOLIDES; APOPTOSIS;
D O I：
10.1080/13102818.2021.1932594
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
In this study, we present initial data for the potential anti-cancer effects of standardized Bulgarian Petasites hybridus root extract against breast cancer cells. The results showed that Butterbur extract (BE) caused a dose-dependent selective reduction in viability with concomitant increase of apoptosis in human breast cancer cells after 72h treatment. We found the highest cytotoxicity of BE to MDA-MB-231 cells (IC50 - 520 mu g/mL), followed by the MCF-7 cancer cell line (IC50 - 865 mu g/mL). At the same time, the extract exhibited very low cytotoxicity to the non-tumorigenic L929 cell line (two-fold higher inhibitory concentration - 1252 mu g/mL). As a result of our experiments we made the conclusion that Butterbur root extract shows selective high cytotoxicity and nucleus alterations in cancer cells comparing to non-cancerous cells.
引用
收藏
页码：853 / 861
页数：9
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