Viral Escape in the Central Nervous System with Multidrug-Resistant Human Immunodeficiency Virus-1

被引：10

作者：

Beguelin, C. ^{[1
]}

Vazquez, M. ^{[1
]}

Bertschi, M. ^{[2
,3
]}

Yerly, S. ^{[4
]}

de Jong, D. ^{[2
,3
]}

Gutbrod, K. ^{[2
,3
]}

Rauch, A. ^{[1
]}

Cusini, A. ^{[1
,5
]}

机构：

[1] Univ Bern, Univ Hosp Bern, Inselspital, Dept Infect Dis, CH-3006 Bern, Switzerland

[2] Univ Hosp Bern, Dept Neurol, Bern, Switzerland

[3] Univ Bern, CH-3006 Bern, Switzerland

[4] Univ Hosp Geneva, Lab Virol, Geneva, Switzerland

[5] Cantonal Hosp, Infect Dis Unit, Chur, Switzerland

来源：

OPEN FORUM INFECTIOUS DISEASES | 2016年 / 3卷 / 01期

关键词：

central nervous system; HIV; K65R; viral escape; multidrug-resistant; ANTIRETROVIRAL THERAPY; CEREBROSPINAL-FLUID; TISSUES; TROPISM; BRAIN;

D O I：

10.1093/ofid/ofv210

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

In this study, we report the case of a patient infected with human immunodeficiency virus (HIV)-1 who developed ataxia and neurocognitive impairment due to viral escape within the central nervous system (CNS) with a multidrug-resistant HIV-1 despite long-term viral suppression in plasma. Antiretroviral therapy optimization with drugs with high CNS penetration led to viral suppression in the CSF, regression of ataxia, and improvement of neurocognitive symptoms.

引用

页数：4

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