Nephrotoxicity of hydroxyethyl starch 130/0.4 infusion in patients receiving coronary artery bypass surgery: a retrospective study

被引：0
|
作者：
You, Jia [1 ,2 ]
Huang, He [1 ]
Bao, Xiaohang [1 ]
Yu, Dan [1 ]
Chen, Qin [1 ]
Yang, Tiande [1 ]
机构：
[1] Third Mil Med Univ, Xinqiao Hosp, Dept Anesthesiol, Chongqing 400037, Peoples R China
[2] Med Team 91793 Troop, Ledong 572528, Hainan Province, Peoples R China
来源：
INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE | 2016年 / 9卷 / 02期
关键词：
Bypass; nephrotoxicity; hydroxyethyl starch; ACUTE KIDNEY INJURY; RENAL-FUNCTION; SEVERE SEPSIS; CYSTATIN-C; CARDIOPULMONARY BYPASS; MOLECULAR-WEIGHT; CARDIAC-SURGERY; METAANALYSIS; MORTALITY; RESUSCITATION;
D O I：
暂无
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Background: Hydroxyethyl starch (HES) is helpful to maintain the stable haemodynamics in patients receiving cardiac surgery. However, there are concerns regarding the nephrotoxicity of HES. Objectives: This study was to evaluate the nephrotoxicity of HES 130/0.4 in patients receiving on-pump coronary artery bypass surgery. Methods: Patients receiving on-pump coronary artery bypass surgery in Xinqiao Hospital between September 1, 2012 and December 31, 2014 were retrospectively reviewed. Acute kidney injury (AKI) was defined according to the RIFLE criteria, and the renal injury (sCystatin C) was compared between patients with and without HES 130/0.4 infusion in the first 72 h after surgery. Results: A total of 149 patients were included. The incidence of AKI within 72 h was similar between two groups, and the risk for AKI (95% CI, 0.979-1.139) was not increased by hetastarch, even at a dose of 37 ml/kg. Conclusion: HES 130/0.4 does not increase the risk for AKI when it is used for the volume therapy in patients receiving coronary artery bypass surgery, and may neither enhance tubular injury nor alter the glomerular filtration.
引用
收藏
页码：4340 / 4347
页数：8
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