Cyclin D1 locus alterations and Rb deletions but not p16(INK4A) promoter hypermethylations are associated with an inferior outcome in multiple myeloma.

被引:0
|
作者
Krämer, A
Schultheis, B
Hegenbart, U
Neben, K
Goldschmidt, H
Hehlmann, R
Ho, AD
机构
[1] Univ Heidelberg, Med Klin & Poliklin 5, Heidelberg, Germany
[2] Univ Heidelberg, Med Klin Mannheim 3, Heidelberg, Germany
[3] Univ Leipzig, Abt Hamatol & Onkol, Leipzig, Germany
关键词
D O I
暂无
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
1567
引用
收藏
页码:372A / 372A
页数:1
相关论文
共 50 条
  • [41] P16INK4a promoter hypermethylation is frequently found in multiple myeloma and is associated with silencing of the p16INK4a gene.
    Willer, A
    Krämer, A
    Schultheis, B
    Saussele, S
    Reiter, A
    Hastka, J
    Hochhaus, A
    Hegenbart, U
    Goldschmidt, H
    Hehlmann, R
    BLOOD, 1998, 92 (10) : 258A - 258A
  • [42] Concomitant analysis of p16/INK4, cyclin D1, and retinoblastoma protein expression in esophageal squamous cell carcinoma
    Nakamura, T
    Ide, H
    Eguchi, R
    Hayashi, K
    Takasaki, K
    HEPATO-GASTROENTEROLOGY, 2003, 50 (53) : 1321 - 1326
  • [43] Identification of CDK4 sequences involved in cyclin D1 and p16 binding
    Coleman, KG
    Wautlet, BS
    Morrissey, D
    Mulheron, J
    Sedman, SA
    Brinkley, P
    Price, S
    Webster, KR
    JOURNAL OF BIOLOGICAL CHEMISTRY, 1997, 272 (30) : 18869 - 18874
  • [44] The inhibitor of cyclin-dependent kinase 4a/alternative reading frame (INK4a/ARF) locus encoded proteins p16INK4a and p19ARF repress cyclin D1 transcription through distinct cis elements
    D'Amico, M
    Wu, KM
    Fu, MF
    Rao, M
    Albanese, C
    Russell, RG
    Lian, H
    Bregman, D
    White, MA
    Pestell, RG
    CANCER RESEARCH, 2004, 64 (12) : 4122 - 4130
  • [45] Alterations of P53-Rb pathway parameters P53, P14ARF, Mdm2, Rb, P16INK4 and cyclin D1 in malignant mesothelioma
    Brambilla, E
    Lantuejoul, S
    Sturm, N
    Claraz, C
    Brichon, PY
    Galateau, F
    Brambilla, C
    LABORATORY INVESTIGATION, 2002, 82 (01) : 316A - 316A
  • [46] Alterations of P53-Rb pathway parameters P53, P14ARF, Mdm2, Rb, P16INK4 and cyclin D1 in malignant mesothelioma
    Brambilla, E
    Lantuejoul, S
    Sturm, N
    Claraz, C
    Brichon, PY
    Galateau, F
    Brambilla, C
    MODERN PATHOLOGY, 2002, 15 (01) : 316A - 316A
  • [47] Differential effect of epigenetic alterations and genomic deletions of CDK inhibitors [p16(INK4a), p15(INK4b), p14(ARF)] in mantle cell lymphoma
    Hutter, G
    Scheubner, M
    Zimmermann, Y
    Kalla, J
    Katzenberger, T
    Hübler, K
    Roth, S
    Hiddemann, W
    Ott, G
    Dreyling, M
    GENES CHROMOSOMES & CANCER, 2006, 45 (02): : 203 - 210
  • [48] Divergent cyclin B1 expression and Rb/p16/cyclin D1 pathway aberrations among pulmonary neuroendocrine tumors
    Igarashi, T
    Jiang, SX
    Kameya, T
    Asamura, H
    Sato, Y
    Nagai, K
    Okayasu, I
    MODERN PATHOLOGY, 2004, 17 (10) : 1259 - 1267
  • [49] Abnormalities of the RB1 pathway in ovarian serous papillary carcinoma as determined by overexpression of the p16(INK4A) protein
    Armes, Jane E.
    Lourie, Rohan
    de Silva, Melanie
    Stamaratis, Georgia
    Boyd, Alison
    Kumar, Beena
    Price, Gareth
    Hyde, Simon
    Allen, David
    Grant, Peter
    Venter, Deon J.
    INTERNATIONAL JOURNAL OF GYNECOLOGICAL PATHOLOGY, 2005, 24 (04) : 363 - 368
  • [50] Polymorphism of p16INK4A and cyclin D1 in adenocarcinomas of the upper gastrointestinal tract
    Helene Geddert
    Sibylle Kiel
    Rainer B. Zotz
    Jianhui Zhang
    Reinhart Willers
    Helmut E. Gabbert
    Mario Sarbia
    Journal of Cancer Research and Clinical Oncology, 2005, 131 : 803 - 808