Synthesis of self-assembling arylopeptoid bearing hydrophilic polymer on the basis of soluble polymer-supported liquid-phase synthesis

被引：4

作者：

Tsuzuki, Tomoya ^{[1
]}

Katagiri, Hiroshi ^{[2
]}

Kitamura, Yoshiaki ^{[1
,3
]}

Kitade, Yukio ^{[1
,3
,4
]}

Ikeda, Masato ^{[1
,3
,4
]}

机构：

[1] Gifu Univ, Grad Sch Engn, Dept Biomol Sci, 1-1 Yanagido, Gifu 5011193, Japan

[2] Yamagata Univ, Grad Sch Sci & Engn, 4-3-16 Jonan, Yonezawa, Yamagata 9928510, Japan

[3] Gifu Univ, Dept Chem & Biomol Sci, Fac Engn, 1-1 Yanagido, Gifu 5011193, Japan

[4] Gifu Univ, United Grad Sch Drug Discovery & Med Informat Sci, 1-1 Yanagido, Gifu 5011193, Japan

来源：

TETRAHEDRON | 2016年 / 72卷 / 43期

基金：

日本学术振兴会;

关键词：

Self-assembly; Peptidomimetics; Oligomer; Polymer-supported synthesis; DRUG-DELIVERY; PEPTOIDS; SEQUENCE;

D O I：

10.1016/j.tet.2016.09.022

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

We describe a new polymer-supported liquid-phase submonomer synthesis (LPSS) protocol for the construction of self-assembling arylopeptoids using polyethylene glycol monomethyl ether (MPEG) as a hydrophilic polymer support. Self-assembling properties of arylopeptoids bearing MPEG (without cleavage from the polymer support for the synthesis) in aqueous media was investigated using fluorescence probe method, dynamic light scattering, and transmission electron microscopy. We found that an arylopeptoid pentamer bearing MPEG exhibits self-assembling ability to form spherical-shaped nanostructures. (C) 2016 Elsevier Ltd. All rights reserved.

引用

页码：6886 / 6891

页数：6

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