Preparation and antimalarial activities of ⟪4 trioxaquines⟫, new modular molecules with a trioxane skeleton linked to a 4-aminoquinoline

被引：0
|
作者：
Dechy-Cabaret, O
Benoit-Vical, F
Robert, A
Meunier, B
机构：
[1] CNRS, Chim Coordinat Lab, F-31077 Toulouse 4, France
[2] INSERM, F-75654 Paris 13, France
来源：
ACTUALITE CHIMIQUE | 2001年 / 09期
关键词：
aminoquinoline; drug research; malaria; peroxide; trioxaquine;
D O I：
暂无
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Trioxaquines are new antimalarial drugs which combine two active fragments (an aminoquinoline and a trioxane) with independant modes of action covalently linked within a single molecule. This strategy, which can be characterized as a much less than covalent bitherapy much greater than allowed us to obtain modular molecules with high antimalarial activity in vitro either on chloroquine sensitive or on chloroquine resistant Plasmodium falciparum strains.
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页码：9 / 11
页数：3
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