Ribofuranose as a carrier of tetraoxane and 4-aminoquinoline antimalarial pharmacophores

被引：2
|
作者：
Opsenica, Igor M. [1 ]
Smith, Kirsten K. [2 ]
Gerena, Lucia [2 ]
Gaica, Sandra [3 ]
Solaja, Bogdan A. [1 ]
机构：
[1] Univ Belgrade, Fac Chem, Belgrade 11001, Serbia
[2] Walter Reed Army Inst Res, Div Expt Therapeut, Washington, DC 20307 USA
[3] Inst Chem Technol & Met, Belgrade 11000, Serbia
来源：
JOURNAL OF THE SERBIAN CHEMICAL SOCIETY | 2008年 / 73卷 / 11期
关键词：
tetraoxanes; 4-aminoquinolines; malaria; P; falciparum;
D O I：
10.2298/JSC0811021O
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Several tetraoxane and 4-aminoquinoline molecules were prepared in order to examine the influence of ribofuranose as a carrier molecule on the antimalarial activity of test compounds. The synthesized compounds showed pronounced antimalarial activity against Plasmodium falciparum chloroquine susceptible D6, chloroquine resistant W2 and multidrug-resistant TM91C235 (Thailand) strains. The aminoquinoline derivative 4 was more active against W2 and TM91C235 strains than the control compounds (CQ and MFQ).
引用
收藏
页码：1021 / 1025
页数：5
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