Early childhood infection by human herpesvirus 8 in Zambia and the role of human immunodeficiency virus type 1 coinfection in a highly endemic area

被引:44
|
作者
Minhas, Veenu [1 ,2 ]
Crabtree, Kay L. [1 ,2 ]
Chao, Ann [3 ]
M'soka, Tendai J. [4 ]
Kankasa, Chipepo [4 ]
Bulterys, Marc [3 ,5 ]
Mitchell, Charles D. [6 ]
Wood, Charles [1 ,2 ]
机构
[1] Univ Nebraska, Nebraska Ctr Virol, Lincoln, NE USA
[2] Univ Nebraska, Sch Biol Sci, Lincoln, NE USA
[3] US Ctr Dis Control & Prevent, Global AIDS Program, Lusaka, Zambia
[4] Univ Teaching Hosp, Dept Paediat & Child Hlth, Lusaka, Zambia
[5] Ctr Dis Control & Prevent, Natl Ctr HIV Viral Hepatitis STD & TB Prevent, Atlanta, GA USA
[6] Univ Miami, Sch Med, Dept Pediat, Miami, FL USA
关键词
herpesvirus; 8; human; HIV-1; infection; sarcoma; Kaposi; Zambia;
D O I
10.1093/aje/kwn125
中图分类号
R1 [预防医学、卫生学];
学科分类号
1004 ; 120402 ;
摘要
Kaposi's sarcoma occurs at high incidence among Zambian adults and children, but there is a paucity of data on human herpesvirus 8 (HHV-8) incidence and routes of infection, especially in children. Between 1998 and 2004, the authors conducted a prospective study of viral transmission in a cohort of 684 children in Lusaka, Zambia, to estimate the annual incidence of HHV-8 from birth through 48 months of age. Maternal and pediatric human immunodeficiency virus type 1 (HIV-1) infection status was also determined. The results, based on 1,532 child-years of follow-up, showed that HHV-8 seroconversion occurs early in life. The incidence rate of HHV-8 seroconversion was 13.8 infections per 100 child-years by 48 months of age. HIV-1-infected children were at substantially higher risk for HHV-8 seroconversion (adjusted hazard ratio = 4.60, 95% confidence interval: 2.93, 7.22). Maternal HIV-1 and HHV-8 infection status were not independently associated with risk of HHV-8 seroconversion in the child. HHV-8 antibody titers in children followed at all consecutive time points revealed seroreversion of HHV-8 antibodies, with undetectable titers in some children at one or more time points after seroconversion. These results demonstrate that cross-sectional serologic screening probably underestimates true HHV-8 seroprevalence in young Zambian children because of fluctuations in detectable antibody titers.
引用
收藏
页码:311 / 320
页数:10
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