The JAK-STAT signaling pathway is differentially activated in CALR-positive compared with JAK2V617F-positive ET patients

被引：34
|
作者：
Lau, Winnie W. Y. [1 ,2 ,3 ]
Hannah, Rebecca [1 ,2 ,3 ]
Green, Anthony R. [1 ,2 ,3 ,4 ]
Goettgens, Bertie [1 ,2 ,3 ]
机构：
[1] Univ Cambridge, Cambridge Inst Med Res, Cambridge, England
[2] Univ Cambridge, Wellcome Trust, Stem Cell Inst, Med Res Council, Cambridge, England
[3] Univ Cambridge, Dept Haematol, Cambridge, England
[4] Addenbrookes Hosp, Dept Haematol, Cambridge CB2 2QQ, England
来源：
BLOOD | 2015年 / 125卷 / 10期
基金：
英国生物技术与生命科学研究理事会; 英国惠康基金; 英国医学研究理事会;
关键词：
MYELOPROLIFERATIVE NEOPLASMS; ENRICHMENT ANALYSIS; MUTATIONS; CELLS;
D O I：
10.1182/blood-2014-12-618074
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
引用
收藏
页码：1679 / 1681
页数：3
相关论文
共 50 条
  • [21] Reversine exhibits antineoplastic activity in JAK2V617F-positive myeloproliferative neoplasms
    Lima, Keli
    Elias Godoy Carlos, Jorge Antonio
    Alves-Paiva, Raquel de Melo
    Vicari, Hugo Passos
    de Souza Santos, Fabio Pires
    Hamerschlak, Nelson
    Costa-Lotufo, Leticia Veras
    Traina, Fabiola
    Machado-Neto, Joao Agostinho
    SCIENTIFIC REPORTS, 2019, 9 (1)
  • [22] Reversine exhibits antineoplastic activity in JAK2V617F-positive myeloproliferative neoplasms
    Keli Lima
    Jorge Antonio Elias Godoy Carlos
    Raquel de Melo Alves-Paiva
    Hugo Passos Vicari
    Fábio Pires de Souza Santos
    Nelson Hamerschlak
    Leticia Veras Costa-Lotufo
    Fabiola Traina
    João Agostinho Machado-Neto
    Scientific Reports, 9
  • [23] THE ROLE OF THE THROMBOPOIETIN RECEPTOR (MPL) IN JAK2V617F-POSITIVE MYELOPLROLIFERATIVE NEOPLASMS
    Behrens, Kira
    Viney, Elizabeth
    Willson, Tracy
    Babon, Jeff
    Nicola, Nicos
    Alexander, Warren
    EXPERIMENTAL HEMATOLOGY, 2019, 76 : E6 - E6
  • [24] A germline JAK2 SNP is associated with predisposition to the development of JAK2V617F-positive myeloproliferative neoplasms
    Kilpivaara, Outi
    Mukherjee, Semanti
    Schram, Alison M.
    Wadleigh, Martha
    Mullally, Ann
    Ebert, Benjamin L.
    Bass, Adam
    Marubayashi, Sachie
    Heguy, Adriana
    Garcia-Manero, Guillermo
    Kantarjian, Hagop
    Offit, Kenneth
    Stone, Richard M.
    Gilliland, D. Gary
    Klein, Robert J.
    Levine, Ross L.
    NATURE GENETICS, 2009, 41 (04) : 455 - 459
  • [25] A germline JAK2 SNP is associated with predisposition to the development of JAK2V617F-positive myeloproliferative neoplasms
    Outi Kilpivaara
    Semanti Mukherjee
    Alison M Schram
    Martha Wadleigh
    Ann Mullally
    Benjamin L Ebert
    Adam Bass
    Sachie Marubayashi
    Adriana Heguy
    Guillermo Garcia-Manero
    Hagop Kantarjian
    Kenneth Offit
    Richard M Stone
    D Gary Gilliland
    Robert J Klein
    Ross L Levine
    Nature Genetics, 2009, 41 : 455 - 459
  • [26] JAK-STAT PATHWAY IN MYELOPROLIFERATIVE NEOPLASMS: FROM JAK2 V617F TO CALRETICULIN MUTANTS
    Constantinescu, S. N.
    BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY, 2017, 121 : 31 - 31
  • [27] JAK2V617F-negative ET patients do not display constitutively active JAK/STAT signaling
    Schwernmers, Sven
    Will, Britta
    Waller, Cornelius E.
    Abdulkarim, Khadija
    Johansson, Peter
    Andreasson, Bjorn
    Pahl, Heike L.
    EXPERIMENTAL HEMATOLOGY, 2007, 35 (11) : 1695 - 1703
  • [28] Prevalence of JAK2V617F, CALR in Philadelphia Positive and Negative Myeloproliferative Neoplasm
    Abedi, Elham
    Karimi, Mehran
    Cohan, Nader
    Haghpanah, Sezaneh
    Yaghobi, Ramin
    Azarpira, Negar
    Moghadam, Mohamad
    Bayat, Elahe
    Farokhian, Farnoush
    Mohammadi, Hamid
    Lak, Elahe Razmara
    Golafshan, Habib Allah
    Ramzi, Mani
    GALEN MEDICAL JOURNAL, 2021, 10
  • [29] JAK2V617F-Positive Endothelial Cells Display Pro-Thrombotic Characteristics
    Guadall, Anna
    Lesteven, Elodie
    Letort, Gil
    Toor, Sarah Awan
    Pognant, Doriane
    Brusson, Megane
    Verger, Emmanuelle
    Larghero, Jerome
    Vanneaux, Valerie
    Chomienne, Christine
    El Nemer, Wassim
    Cassinat, Bruno
    Kiladjian, Jean-Jacques
    BLOOD, 2016, 128 (22)
  • [30] JAK2V617F-positive endothelial cells contribute to clotting abnormalities in myeloproliferative neoplasms
    Etheridge, S. Leah
    Roh, Michelle E.
    Cosgrove, Megan E.
    Sangkhae, Veena
    Fox, Norma E.
    Chen, Junmei
    Lopez, Jose A.
    Kaushansky, Kenneth
    Hitchcock, Ian S.
    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2014, 111 (06) : 2295 - 2300
12345