Contribution of mesocosm testing to a single-step and exposure-driven environmental risk assessment of engineered nanomaterials

被引：23

作者：

Auffan, Melanie ^{[1
,2
,4
]}

Masion, Armand ^{[1
,2
]}

Mouneyrac, Catherine ^{[3
]}

de Garidel-Thoron, Camille ^{[1
,2
]}

Hendren, Christine Ogilvie ^{[4
]}

Thiery, Alain ^{[2
,5
]}

Santaella, Catherine ^{[2
,6
]}

Giamberini, Laure ^{[7
]}

Bottero, Jean-Yves ^{[1
,2
]}

Wiesner, Mark R. ^{[4
]}

Rose, Jerome ^{[1
,2
,4
]}

机构：

[1] Aix Marseille Univ, Coll France, Europole Arbois, CEREGE,CNRS,IRD,INRA, BP 80, F-13545 Aix En Provence, France

[2] Labex SERENADE, Europole Arbois, BP 80, F-13545 Aix En Provence, France

[3] Univ Catholique Ouest, Lab Mer Mol Sante, F-49000 Angers, France

[4] Duke Univ, CEINT, Box 90287,121 Hudson Hall, Durham, NC 27708 USA

[5] Aix Marseille Univ, Univ Avignon, IMBE, CNRS,IRD, Marseille, France

[6] Aix Marseille Univ, LEMIRE, CEA, CNRS, F-13108 St Paul Les Durance, France

[7] Univ Lorraine, LIEC, CNRS, UMR 7360, Campus Bridoux,Rue Gen Delestraint, F-57070 Metz, France

来源：

NANOIMPACT | 2019年 / 13卷

关键词：

NANOPARTICLES; TRANSFORMATION; FATE;

D O I：

10.1016/j.impact.2018.12.005

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

Environmental risk assessment of nanomaterials generally relies on a decision-tree based strategy which provides guidance and protocols for the determination of a collection of hazard end-points. Mesocosm testing is based on a different approach. This method consists in monitoring the evolution of a re-created miniature ecosystem subsequent to a nanomaterial contamination. The only decision in this risk assessment strategy is the definition of an environmentally relevant exposure scenario (incl. dose), which, given current analytical capabilities, may unfavorably affect the nature and precision of parameters and endpoints to be determined. Despite these limitations, mesocosm testing bears clear advantages for the determination of both exposure and hazard in a single experiment, and for producing dependable and intercomparable data.

引用

页码：66 / 69

页数：4