DNA oxidation mediated by [Ru(bpy)2tatp]2+ upon incorporation of [Co(phen)3]3+

被引：5
|
作者：
Xu, Shidang [1 ]
Lu, Chunjie [1 ]
Shao, Jiangyang [1 ]
Li, Qian [1 ]
Li, Hong [1 ]
Li, Weishan [1 ]
机构：
[1] S China Normal Univ, Key Lab Technol Electrochem Energy Storage & Powe, Sch Chem & Environm, Guangzhou 510006, Guangdong, Peoples R China
来源：
JOURNAL OF ELECTROANALYTICAL CHEMISTRY | 2011年 / 661卷 / 02期
基金：
高等学校博士学科点专项科研基金;
关键词：
DNA; Ruthenium(II) complex; Cobalt(III) complex; ITO; Oxidation; GLASSY-CARBON ELECTRODES; FLASH-QUENCH TECHNIQUE; ITO ELECTRODE; POLYPYRIDYL COMPLEXES; DAMAGE; PHOTOCLEAVAGE; GUANINE; BINDING; COBALT(III); TRIS(2,2'-BIPYRIDINE)RUTHENIUM(II);
D O I：
10.1016/j.jelechem.2011.07.047
中图分类号：
O65 [分析化学];
学科分类号：
070302 ; 081704 ;
摘要：
The electrochemical oxidation of DNA mediated by [Ru(bpy)(2)tatp](2+) (bpy = 2,2'-bipyridine, tatp = 1,4,8,9-tetra-aza-triphenylene) upon incorporation of [Co(phen)(3)](3+) (phen = 1,10-phenanthroline) has been investigated. The results from emission spectra and fluorescence microscope images suggest the formation of an aggregate containing [Ru(bpY)(2)tatp](2+), DNA and [co(phen)(3)](3+) based on the strong interactions. The evidences from repetitive differential pulse voltammograms and cyclic voltammogams reveal that the presence of [Co(phen)(3)](3+) can promote the oxidation of DNA mediated by [Ru(bpy)(2)tatp](2+) on an indium tin oxide (ITO) electrode. The oxidative response of DNA shows a cumulative enhancement with increasing the voltammetric sweeping number, and a stable linear response to DNA is found between 0.001 mM and 0.1 mM. Furthermore, the oxidative mechanism of DNA mediated by [Ru(bpy)(2)tatp](2+) upon incorporation of [Co(phen)(3)](3+) becomes evident, depending on the concentration of DNA and mediators, the structure of mediators and scan rate. The results from this study provide a significant basis for better understanding the oxidative damage of DNA mediated by DNA-binding agents. (C) 2011 Elsevier B.V. All rights reserved.
引用
收藏
页码：287 / 293
页数：7
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