The effect of pre-existing immunity on the capacity of influenza virosomes to induce cytotoxic T lymphocyte activity

被引：6
|
作者：
de Mare, Arjan [1 ]
Bungener, Laura B. [1 ]
Regts, Joke [1 ]
de Vries-Idema, Jacqueline [1 ]
van der Zee, Ate G. J. [2 ]
Witschut, Jan [1 ]
Daemen, Toos [1 ]
机构：
[1] Univ Groningen, Univ Med Ctr Groningen, Mol Virol Sect, Dept Med Microbiol, NL-9700 RB Groningen, Netherlands
[2] Univ Groningen, Dept Gynecol, Univ Med Ctr Groningen, NL-9700 RB Groningen, Netherlands
来源：
VACCINE | 2008年 / 26卷 / 19期
关键词：
virosome; CTL; pre-existing immunity;
D O I：
10.1016/j.vaccine.2008.03.002
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Protein antigens encapsulated in virosomes generated from influenza virus can induce antigen-specific cytotoxic T lymphocyte (CTL) responses. In the present study we determined, in a murine model system, whether pre-existing immunity against influenza virus hampers the induction of a CTL response. CTL induction was only slightly reduced by pre-injection of influenza virus-specific antibodies or pre-exposure to influenza virus. Both pre-treatments resulted in the same level of reduction, suggesting that virus-specific antibodies rather than T cell responses account for the reduction. Furthermore, a booster immunization enhanced CTL activation, indicating that virosome-specific immunity induced by a prime immunization does not hamper the booster effect. In conclusion, CTL induction against virosome-encapsulated protein antigens is not significantly inhibited by pre-existing humoral or cellular immunity against influenza virus. (C) 2008 Elsevier Ltd. All rights reserved.
引用
收藏
页码：2314 / 2321
页数：8
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