Pharmacokinetics and protein binding of linezolid in cerebrospinal fluid and serum in a case of post-neurosurgical bacterial meningitis

被引：14

作者：

Tsuji, Yasuhiro ^{[1
]}

Hiraki, Yoichi ^{[2
]}

Matsumoto, Kana ^{[3
]}

Mizoguchi, Akiko ^{[1
]}

Sadoh, Shinichi ^{[1
]}

Kobayashi, Tsutomu ^{[4
]}

Takemura, Yusuke ^{[5
]}

Sakamoto, Seisaburo ^{[5
]}

Morita, Kunihiko ^{[3
]}

Kamimura, Hidetoshi ^{[6
]}

Karube, Yoshiharu ^{[7
]}

机构：

[1] Sasebo Chuo Hosp, Dept Pharm, Nagasaki 8571195, Japan

[2] Natl Hosp Org, Kumamoto Med Ctr, Dept Pharm, Kumamoto, Japan

[3] Doshisha Womens Coll Liberal Arts, Fac Pharmaceut Sci, Dept Clin Pharmaceut, Kyoto, Japan

[4] Sasebo Chuo Hosp, Dept Internal Med, Nagasaki 8571195, Japan

[5] Sasebo Chuo Hosp, Dept Neurosurg, Nagasaki 8571195, Japan

[6] Fukuoka Univ, Fac Pharmaceut Sci, Dept Pharmaceut & Hlth Care Management, Fukuoka 81401, Japan

[7] Fukuoka Univ, Lab Drug Design & Drug Delivery, Fac Pharmaceut Sci, Fukuoka 81401, Japan

来源：

SCANDINAVIAN JOURNAL OF INFECTIOUS DISEASES | 2011年 / 43卷 / 11-12期

关键词：

Linezolid; bacterial meningitis; protein binding ratio; cerebrospinal fluid; IN-VITRO ACTIVITIES; OXAZOLIDINONE ANTIBACTERIAL; CLINICAL PHARMACOKINETICS; VANCOMYCIN; INFECTIONS; DRAINS;

D O I：

10.3109/00365548.2011.600327

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

We describe a case of bacterial meningitis in a patient administered linezolid (LZD). The ratio of free to total LZD concentrations in cerebrospinal fluid (CSF) was 1 for all measurements, and the LZD concentration in CSF measured at the trough level was almost the same as the free serum concentration.

引用

页码：982 / 985

页数：4

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