Current research acknowledges the unprecedented effects of the Fourth Industrial Revolution (4IR) on socio-economic development, human interpersonal relations, and day-to-day life. It is worth scrutinising how this shift may cost infrastructural development, economic growth, and human development worldwide, shaping the planet's future. Within the scope of maintaining human's centrality in the era of 4IR, it is critical to draw serious attention to the relevance of spirituality in developing new and existing technologies. This study examines the Muslim framework of spirituality and its proposed pathways for 4IR. This study further concludes that for Muslims, spirituality adds meaning and value to the ethical design, production, and management of 4IR and enables it to better serve the composition of human societies and their emerging needs without harming the well-being of the planet, its resources, or the future of humankind.