Drug therapy: EGFR antagonists in cancer treatment

被引：1665

作者：

Ciardiello, Fortunato ^{[1
]}

Tortora, Giampaolo ^{[2
]}

机构：

[1] Univ Naples 2, Div Med Oncol, Dept Expt & Clin Med & Surg F Magrassi & A Lanzar, I-80131 Naples, Italy

[2] Univ Naples Federico II, Div Med Oncol, Dept Mol & Clin Endocrinol & Oncol, Naples, Italy

来源：

NEW ENGLAND JOURNAL OF MEDICINE | 2008年 / 358卷 / 11期

关键词：

D O I：

10.1056/NEJMra0707704

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Functional activation of growth factors and receptors of the epidermal growth factor receptor (EGFR) family occurs in most epithelial-cell cancers, rendering EGFR a target for cancer treatment. This article discusses the mechanisms of action of EGFR inhibitors, their anticancer activity, and clinical issues concerning their use in the treatment of patients with cancer. Copyright © 2008 Massachusetts Medical Society. All rights reserved.

引用

页码：1160 / 1174

页数：15

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