Regulation and roles of RNA modifications in aging-related diseases

被引:34
|
作者
Jiapaer, Zeyidan [1 ,2 ]
Su, Dingwen [3 ]
Hua, Lingyang [4 ]
Lehmann, Helge Immo [5 ,6 ]
Gokulnath, Priyanka [5 ,6 ]
Vulugundam, Gururaja [7 ]
Song, Shannan [1 ,2 ]
Zhang, Lingying [1 ,2 ]
Gong, Ye [4 ]
Li, Guoping [5 ,6 ]
机构
[1] Xinjiang Univ, Coll Life Sci Technol, Urumqi, Peoples R China
[2] Xinjiang Key Iab Biol Resources & Genet, Urumqi, Peoples R China
[3] Max Planck Gesell, Friedrich Miescher Lab, Tubingen, Germany
[4] Fudan Univ, Shanghai Med Coll, Huashan Hosp, Dept Neurosurg, Shanghai, Peoples R China
[5] Massachusetts Gen Hosp, Cardiovasc Res Ctr, Boston, MA 02215 USA
[6] Harvard Med Sch, Boston, MA 02115 USA
[7] Natl Res Council Italy, Inst Biochem & Cellular Biol, Naples, Italy
基金
中国国家自然科学基金;
关键词
aging; aging-related disease; epitranscriptome; RNA modification; MESSENGER-RNA; NUCLEAR-RNA; ALZHEIMERS-DISEASE; EDITING CONTROLS; METHYLATION; REVEALS; METHYLTRANSFERASE; GENE; PSEUDOURIDYLATION; 5-METHYLCYTOSINE;
D O I
10.1111/acel.13657
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
With the aging of the global population, accumulating interest is focused on manipulating the fundamental aging-related signaling pathways to delay the physiological aging process and eventually slow or prevent the appearance or severity of multiple aging-related diseases. Recently, emerging evidence has shown that RNA modifications, which were historically considered infrastructural features of cellular RNAs, are dynamically regulated across most of the RNA species in cells and thereby critically involved in major biological processes, including cellular senescence and aging. In this review, we summarize the current knowledge about RNA modifications and provide a catalog of RNA modifications on different RNA species, including mRNAs, miRNAs, lncRNA, tRNAs, and rRNAs. Most importantly, we focus on the regulation and roles of these RNA modifications in aging-related diseases, including neurodegenerative diseases, cardiovascular diseases, cataracts, osteoporosis, and fertility decline. This would be an important step toward a better understanding of fundamental aging mechanisms and thereby facilitating the development of novel diagnostics and therapeutics for aging-related diseases.
引用
收藏
页数:19
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