Quantitative analysis and inspection for pharmaceutical polymorphism with injection-seeded terahertz parametric generation technique

被引：0
|
作者：
Mohara, Mizuki [1 ]
Aiko, Kenji [1 ]
Shimura, Kei [1 ]
Ono, Touya [1 ]
机构：
[1] Hitachi High Technol Corp, Hitachinaka, Ibaraki 3128504, Japan
来源：
2018 43RD INTERNATIONAL CONFERENCE ON INFRARED, MILLIMETER, AND TERAHERTZ WAVES (IRMMW-THZ) | 2018年
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中图分类号：
TM [电工技术]; TN [电子技术、通信技术];
学科分类号：
0808 ; 0809 ;
摘要：
Terahertz (THz) spectroscopy with injection-seeded terahertz parametric generation (is-TPG) technique has potential as a nondestructive transmission inspection technique for pharmaceutical tablets because of high peak power THz wave and wide dynamic range. Using a spectrometer with is-TPG technique, enalapril maleate polymorphs and fenoprofen calcium crystalline were identified by their specific absorption peaks. Quantitative analysis of these samples were conducted. The limit of detection of 0.14 wt% of fenoprofen calcium crystalline was obtained.
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页数：2
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